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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海研卉生物科技有限公司
- 英文名:
Recombinant Human TrkB/NTRK2
- 规格:
50ug
Recombinant Human TrkB/NTRK2 (C507)
产品说明(Description)
Recombinant Human Neurotrophic Tyrosine Kinase Receptor Type 2 is produced by our Mammalian expression system and the target gene encoding Cys32-His430 is expressed with a 6His tag at the C-terminus.
Accession #: Q16620
Known as: BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B; NTRK2; TRKB
制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
质量控制(Quality Control)
Bioactivity: Immobilized Human NT-3 (Cat#C079) at 2μg/ml (100 μl/well) can bind Human TrkB-His (Cat#C507).The ED50 of Human TrkB-His (Cat#C507) is 3.777ug/ml.
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
背景(Background)
The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.
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