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Murine IFN-γ (20ug)
IFN-γ是一种酸不稳定性干扰素，由CD4和CD8 T淋巴细胞以及活化的NK细胞产生。IFN-γ受体存在于大多数免疫细胞中，这些细胞通过增加I类MHC蛋白的表面表达来响应IFN-γ信号。这促进了抗原向辅助性T细胞（CD4+）的呈递。抗原呈递细胞以及识别抗原的B淋巴细胞和T淋巴细胞中的IFN-γ信号传导，调节免疫反应的抗原特异性阶段。此外，IFN-γ刺激多种淋巴细胞功能，包括巨噬细胞、NK细胞和中性粒细胞的抗菌和抗肿瘤反应。人源IFN-γ具有物种特异性，仅在人源和灵长类动物细胞中具有生物学活性。
氨基酸序列：
MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI
SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC
预测分子量：15.6 kDa
纯度: ≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度：<1 EU/µg
活性：Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
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文献和实验[1]Lee H, Seidl C, Sun R, Glinka A, Niehrs C. R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun. 2020 Nov 4;11(1):5570. doi: 10.1038/s41467-020-19373-w. PMID: 33149137; PMCID: PMC7642414.
[2]Yuri S, Nishikawa M, Yanagawa N, Jo OD, Yanagawa N. In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells. Stem Cell Reports. 2017 Feb 14;8(2):401-416. doi: 10.1016/j.stemcr.2016.12.011. Epub 2017 Jan 12. PMID: 28089670; PMCID: PMC5311471.
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[4]Rabata A, Fedr R, Soucek K, Hampl A, Koledova Z. 3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis. Front Cell Dev Biol. 2020 Jul 21;8:574. doi: 10.3389/fcell.2020.00574. PMID: 32850782; PMCID: PMC7396690.
[5]Cohn ZJ, Kim A, Huang L, Brand J, Wang H. Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci. 2010;11:72. Published 2010 Jun 10. doi:10.1186/1471-2202-11-72】
[6]Padigel UM, Farrell JP. Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol. 2005;174(10):6340-6345. doi:10.4049/jimmunol.174.10.6340
[7]Xiao H, Du X, Tao Z, et al. Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer. Adv Sci (Weinh). 2024;11(3):e2303894. doi:10.1002/advs.202303894
[8]Sprooten J, Vanmeerbeek I, Datsi A, et al. Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells. Cell Rep Med. 2024;5(1):101377. doi:10.1016/j.xcrm.2023.101377
[9]Purvis GSD, McNeill E, Wright B, Channon KM, Greaves DR. Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation. Cells. 2024;13(11):916. Published 2024 May 26. doi:10.3390/cells13110916
[10]Hering M, Madi A, Sandhoff R, et al. Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma. Nat Commun. 2024;15(1):6067. Published 2024 Jul 18. doi:10.1038/s41467-024-50341-w
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