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- 详细信息
- 用户评价
- 文献和实验
- 技术资料
- 库存：
充足
- 供应商：
Gibco
- 英文名：
Human Slit2-N
- 规格：
5ug
Human Slit2-N (5ug)
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Product Details（产品详情） |
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Size（规格） |
5 µg |
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Species（物种） |
Human（人） |
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Published Species（已发表的物种） |
Mouse（小鼠）, Human（人） |
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Expression system（表达系统） |
HEK293 cells（HEK293 细胞） |
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Amino acid sequence（氨基酸序列） |
QACPAQCSCS GSTVDCHGLA LRSVPRNIPR NTERLDLNGN NITRITKTDF AGLRHLRVLQ LMENKISTIE RGAFQDLKEL ERLRLNRNHL QLFPELLFLG TAKLYRLDLS ENQIQAIPRK AFRGAVDIKN LQLDYNQISC IEDGAFRALR DLEVLTLNNN NITRLSVASF NHMPKLRTFR LHSNNLYCDC HLAWLSDWLR QRPRVGLYTQ CMGPSHLRGH NVAEVQKREF VCSGHQSFMA PSCSVLHCPA ACTCSNNIVD CRGKGLTEIP TNLPETITEI RLEQNTIKVI PPGAFSPYKK LRRIDLSNNQ ISELAPDAFQ GLRSLNSLVL YGNKITELPK SLFEGLFSLQ LLLLNANKIN CLRVDAFQDL HNLNLLSLYD NKLQTIAKGT FSPLRAIQTM HLAQNPFICD CHLKWLADYL HTNPIETSGA RCTSPRRLAN KRIGQIKSKK FRCSAKEQYF IPGTEDYRSK LSGDCFADLA CPEKCRCEGT TVDCSNQKLN KIPEHIPQYT AELRLNNNEF TVLEATGIFK KLPQLRKINF SNNKITDIEE GAFEGASGVN EILLTSNRLE NVQHKMFKGL ESLKTLMLRS NRITCVGNDS FIGLSSVRLL SLYDNQITTV APGAFDTLHS LSTLNLLANP FNCNCYLAWL GEWLRKKRIV TGNPRCQKPY FLKEIPIQDV AIQDFTCDDG NDDNSCSPLS RCPTECTCLD TVVRCSNKGL KVLPKGIPRD VTELYLDGNQ FTLVPKELSN YKHLTLIDLS NNRISTLSNQ SFSNMTQLLT LILSYNRLRC IPPRTFDGLK SLRLLSLHGN DISVVPEGAF NDLSALSHLA IGANPLYCDC NMQWLSDWVK SEYKEPGIAR CAGPGEMADK LLLTTPSKKF TCQGPVDVNI LAKCNPCLSN PCKNDGTCNS DPVDFYRCTC PYGFKGQDCD VPIHACISNP CKHGGTCHLK EGEEDGFWCI CADGFEGENC EVNVDDCEDN DCENNSTCVD GINNYTCLCP PEYTGELCEE KLDFCAQDLN PCQHDSKCIL TPKGFKCDCT PGYVGEHCDI DFDDCQDNKC KNGAHCTDAV NGYTCICPEG YSGLFCEFSP PMV |
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Molecular weight（分子量） |
122.35 kDa |
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Class（类别） |
Recombinant（重组蛋白） |
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Type（类型） |
Protein（蛋白） |
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Purity（纯度） |
98% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin concentration（内毒素浓度） |
<1 EU/µg |
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Activity（活性） |
Determined by its ability to inhibit MC3T3/E1 osteoblasts cell differentiation. |
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Conjugate（偶联物） |
Unconjugated（未偶联） |
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Form（状态） |
Lyophilized（冻干粉） |
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Purification（纯化） |
purified（已纯化） |
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Contains（成分） |
no preservative（不含防腐剂） |
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Storage conditions（储存条件） |
-20°C |
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Applications（应用） |
Tested Dilution（测试稀释度） |
Publications（发表文章数量） |
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Functional Assay (Functional) |
Assay-dependent |
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In vitro Assay (IV) |
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4 Publications |
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Miscellaneous PubMed (Misc) |
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4 Publications |
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Product Specific Information
150-11-1MG will be provided as 5 x 200 µg (150-11-200UG).
150-11-500UG will be provided as multiple 100 µg (150-11-100UG) and 200 µg (150-11-200UG) vials.
Recombinant Human Slit2-N is a 1093 amino acid glycoprotein corresponding to the N-terminal portion of the full length Slit2 precursor, and has a calculated, theoretical molecular weight of 122.35 kDa. Due to glycosylation Slit2-N migrates at an
apparent molecular weight of approximately 120.0-140.0 kDa by SDS-PAGE analysis under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot- specific Certificate of Analysis
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文献和实验[1] Mukovozov I, Huang YW, Zhang Q, et al. The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol. 2015;195(7):3334-3344. doi:10.4049/jimmunol.1500640
[2] Tang W, Tang J, He J, et al. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med. 2015;19(6):1197-1207. doi:10.1111/jcmm.12454
[3] Shrivastava A, Prasad A, Kuzontkoski PM, Yu J, Groopman JE. Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements. Sci Rep. 2015;5:16833. Published 2015 Nov 19. doi:10.1038/srep16833
[4] Xu F, Wu LY, Chang CK, et al. Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes. Nat Commun. 2015;6:8806. Published 2015 Nov 26. doi:10.1038/ncomms9806
[5] Zhou W, Yu W, Xie W, Huang L, Xu Y, Li X. The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cells. Mol Vis. 2011;17:1526-1536.
[6] Guerrero-Cazares H, Lavell E, Chen L, et al. Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development. Stem Cells. 2017;35(7):1860-1865. doi:10.1002/stem.2628
[7] McConnell RE, Edward van Veen J, Vidaki M, Kwiatkowski AV, Meyer AS, Gertler FB. A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion. J Cell Biol. 2016;213(2):261-274. doi:10.1083/jcb.201509062
[8] Mukovozov I, Huang YW, Zhang Q, et al. The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol. 2015;195(7):3334-3344. doi:10.4049/jimmunol.1500640
[9] Qin F, Zhang H, Ma L, et al. Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients. Sci Rep. 2015;5:14430. Published 2015 Sep 24. doi:10.1038/srep14430
, the serogroup B meningococcal polysaccharide when conjugated to a protein carrier still failed to give a significant immune response ( 2 , 3 ). This phenomenon is probably attributed to the molecular mimicry between the polysaccharide and human
Glycosylation is an important issue in heterologous protein production for therapeutic applications. Glycoproteins produced in Pichia pastoris contain high mannose glycan structures that can hamper downstream processing, might be immunogenic
Phenotypic and Genotypic Characterization of N-Acetylation
as the N -acetylation polymorphism. This chapter provides as background a description of some key studies that showed that acetylation was variable in the human population, that it is inherited, and the molecular basis for this phenomenon. Since accurate
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