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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Rat Oncostatin M
- 供应商：
上海研卉生物科技有限公司
- 规格：
100µg
Product Details
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.
Source: E.coli
Synonyms: OSM
AA Sequence: MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Assay #1:Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 μg/ml.
Assay #2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Drechsler, J | Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. | PLoS ONE; 7(8) pge43155 | 0 2012 | 22937020 Show Usages |
| Zhang, P | Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice. | Stem Cell Reports; 6(6) pg914-925 | 14 Jun 2016 | 27237378 Show Usages |
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