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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-8675R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
BDKRB1
- 抗体名:
缓激肽B1受体抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Rabbit,
- 免疫原:
KLH conjugated synthetic peptide derived from Human BDKRB1:161-260/353 <Extracellular>
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
50ul 100ul 200ul
| 英文名称 | BDKRB1 |
| 中文名称 | 缓激肽B1受体抗体 |
| 别 名 | B1 bradykinin receptor; B1BKR; B1R; BDKR B1; BDKRB 1; BDKRB1; BK 1 receptor; BK-1 receptor; bradykinin B1 R; BKB1R; BKR 1; BKR1; BKRB1_HUMAN; BRADY B1; BRADYB1; Bradykinin B1 receptor; Bradykinin receptor 1; bradykinin B1R; Bradykinin receptor B1 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human BDKRB1:161-260/353 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases. Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Subunit: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. SWISS: P46663 Gene ID: 623 Database links: Entrez Gene: 623 Human Omim: 600337 Human SwissProt: P46663 Human Unigene: 525572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Sample: placenta (Mouse) Lysate at 40 ug Lung (Mouse) Lysate at 40 ug Primary: Anti-BDKRB1 (bs-8675R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 60 kD |
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文献和实验细胞碎片等。但与自身抗原的亲和力相对较低但具有广泛的交叉反应性(po1yreactivity)。有假说认为天然自身抗体是由胃肠道内的常住菌丛诱导产生的。然而新生儿脐带血中自身抗体浓度也很高,出生几天后才下降为“正常水平”。此外,无菌环境下培养的小鼠血清中也存在天然自身抗体。另一种假说认为它们来自死亡的自身反应性B1细胞。CD5+Dl细胞占人胎儿B细胞总数的40%一60%,占成人淋巴结B细胞的2%~3%。这群B细胞能分泌IgM类抗体,也参与某些自身免疫反应。 2.病理性自身抗体 受抗原刺激生成
有:b1受体密度下降,由70%~80%降为50%;b2和a受体密度上升,由20%~30%升为50%;与b1/b2受体偶联的兴奋性G蛋白(Gs蛋白)、腺苷酸环化酶以及细胞内的cAMP浓度则均降低。CHF时,b受体激酶(bARK1)活性升高,增加b1受体的磷酸化而使b受体脱敏感。通常,激活的b1受体通过蛋白激酶A (PKA)使受磷蛋白(phospholamban)磷酸化,增强肌浆网对Ca2+的再摄取。若b1受体下调则使受磷蛋白脱磷酸化,抑制肌浆网对Ca2+的再摄取和释放,从而影响心肌的收缩和舒张功能。此外,b
4.神经系统 在中枢神经系统,NO作为神经递质或调质发挥作用,但NO的作用部位和性质尚不清楚。 多肽类 编辑本段 回目录 一、激肽类 激肽(kinins)分为缓激肽(bradykinin)和胰激肽(kallidin)二种,它们具有类似的生物学作用。能够扩张血管、收缩平滑肌和提高毛细血管通透性。其扩张心、肾、肠、骨骼肌和肝内血管的作用。比histamine强10倍。Kinin可引起呼吸道平滑肌、子宫平滑肌和大多数胃肠平滑肌收缩,因此kinin
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