- ¥1380 - 2200
- LMAI Bio
- LM-8544R
- 进口/国产
- 2026年05月07日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Monkey, Macaque,Orangutan
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8544R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
GABR B3
- 抗体名：
G氨基丁酸受体3抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Monkey, Macaque,Orangutan
- 免疫原：
KLH conjugated synthetic peptide derived from human GABR B3/GABA A Receptor beta 3:31-130/473 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | GABR B3 |
| 中文名称 | G氨基丁酸受体3抗体 |
| 别 名 | GABA A Receptor beta 3; ECA5; GABA alpha receptor beta-2 subunit; GABA(A) receptor subunit beta-3; GABAA receptor beta 3 subunit; GABAA receptor subunit beta 3; GABR B3; Gabrb3; Gamma aminobutyric acid (GABA) A receptor beta 3; Gamma aminobutyric acid receptor subunit beta 3; Gamma-aminobutyric acid receptor subunit beta-3; GBRB3_HUMAN; MGC9051. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Monkey, Macaque,Orangutan |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABR B3/GABA A Receptor beta 3:31-130/473 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Subunit: Binds UBQLN1. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Subcellular Location: Cell junction; synapse; postsynaptic cell membrane. Cell membrane. DISEASE: Note=Defects in GABRB3 are associated with chronic insomnia, a condition of inability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition. Defects in GABRB3 are the cause of childhood absence epilepsy type 5 (ECA5) [MIM:612269]. ECA5 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Absence seizures may either remit or persist into adulthood. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily. SWISS: P28472 Gene ID: 2548 Database links: Entrez Gene: 2548 Human Entrez Gene: 14387 Mouse Entrez Gene: 367562 Rat Omim: 606800 Human SwissProt: P10253 Human SwissProt: P70699 Mouse SwissProt: Q6P7A9 Rat Unigene: 1437 Human Unigene: 4793 Mouse Unigene: 162368 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-GABR B3 (bs-8544R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD  Sample: Cerebrum (Mouse) Lysate at 40 ug Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-GABR B3 (bs-8544R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD  Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-GABR B3 (bs-8544R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 48 kD  Blank control(blue):RSC96 (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti- GABR B3 antibody(bs-8544R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验：53007ES） 内源性胃肠道多肽激素，可刺激胃壁细胞分泌胃酸；通过结合胆囊收缩素 B 受体（CCKBR）升高胞内钙离子浓度、促进磷脂酰肌醇合成并激活蛋白激酶 C；参与胃上皮细胞增殖与分化调控，是消化道类器官研究核心试剂。 肠类器官、肝类器官培养体系中添加胃泌素，可显著延长类器官存活时间。 储存母液配制方案：取 1 mg 粉末溶于 2.38 mL 1% 氨氺溶液，配制成 0.2 mM 母液，分装后 - 20℃冻存。 推荐工作浓度：10 nM 6. 烟酰胺（维生素 B3，货号：51402
反应(cross reaction)。 抗体分子可有单体、双体和五聚体，因此结合抗原决定簇的数目(结合价)也不相同。Fab段为单价，不能产生凝集反应和沉淀反应。F(ab')2和单体Ig(如IgG、IgD、IgE)为双价。双体分泌型IgA有4价。五聚体IgM理论上应为10价，但实际上由于立体构型的空间位阻，一般只有5个结合点可结合抗原。 B细胞表面Ig(SmIg)是特异性识别抗原的受体，成熟B细胞主要表达SmIgM和SmIgD，同一B细胞克隆表达不同类SmIg其识别抗原的特异性是相同
2) CH（ε） CL（κ） G1ma(1)、x(2)、f(3)、z(17) G2m n(23) G3mb1(5)、c3(6)、b5(10)、b0、(11)b3(13)、b4(14)、s(15)、t(16)、g1(21)、c5(24)、u(26)、v(27)、g1(28) G4m 4a(1)、4b(1) A2m1、2 Em
技术资料暂无技术资料 索取技术资料
