- ¥1380 - 2200
- LMAI Bio
- LM-5799R
- 进口/国产
- 2025年12月29日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5799R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
BAG3
- 抗体名：
Bcl2抑凋亡蛋白Bag3抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human BAG3:441-540/575
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | BAG3 |
| 中文名称 | Bcl2抑凋亡蛋白Bag3抗体 |
| 别 名 | BAG 3; BAG family molecular chaperone regulator 3; BAG-3; Bag3; BAG3_HUMAN; y Bcl 2 binding protein; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; BCL2 associated athanogene 3; BCL2 binding athanogene 3; BIS; Docking protein CAIR 1; Docking protein CAIR-1. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BAG3:441-540/575 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6. DISEASE: Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH) [MIM:613881]. CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Similarity: Contains 1 BAG domain. Contains 2 WW domains. SWISS: O95817 Gene ID: 9531 Database links: Entrez Gene: 9531 Human Entrez Gene: 29810 Mouse Entrez Gene: 293524 Rat Omim: 603883 Human SwissProt: O95817 Human SwissProt: Q9JLV1 Mouse Unigene: 523309 Human Unigene: 84073 Mouse Unigene: 46304 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验体,从而激活凋亡。 5、FasL 也是一个单一跨膜蛋白。FasL 既可通过与之相互作用杀死相邻细胞，也可激活细胞自身的Fas而自杀。 （二）Apaf1- caspase活化蛋白 1、Caspase-8裂解 Bid 使其 C-端域易位至线粒体中。 2、Bid及其它 Bcl2家族促凋亡蛋白的作用导致线粒体释放细胞色素C。. 3、Bcl2抑制cytochrome c释放。 4、Cytochrome c 在胞浆中与Apaf-1结合。Apaf-1/cytochrome c经需能的寡聚化形成大的蛋白
个内源性表达的细胞周期基因。为此我们使用LightCycler® 480实时荧光定量PCR仪和RealTime ready细胞周期检测预制多孔板。用特异抗体和流式细胞术测定天冬氨酸特异性半胱氨酸蛋白酶-3的激活。在这个分析中，我们发现C24ORF17和BARD1基因下调后，天冬氨酸特异性半胱氨酸蛋白酶-3的激活增加了。为了确定编码蛋白在凋亡诱导中的作用，在本研究中我们使用RealTime ready凋亡检测预制多孔板和LightCycler® 480仪器，通过qRT-PCR分析了当通过RNAi而表达
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