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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-8267R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
GIMAP1
- 抗体名:
GTP酶IMAP家族成员1抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Horse, Rabbit,
- 免疫原:
KLH conjugated synthetic peptide derived from human GIMAP1:31-130/306
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | GIMAP1 |
| 中文名称 | GTP酶IMAP家族成员1抗体 |
| 别 名 | GIMA1_HUMAN; GIMAP1; GTPase IMAP family member 1; hIMAP1; Immunity-associated protein 1. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GIMAP1:31-130/306 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP1 (GTPase, IMAP family member 1), also known as IMAP1 (immunity-associated protein 1), HIMAP1 or IMAP38, is a 306 amino acid single-pass type IV membrane protein of the endoplasmic reticulum (ER) belonging to the GIMAP family. Encoded by a gene located on human chromosome 7, GIMAP1 is expressed primarily in spleen with lower levels found in lymph node. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). Subcellular Location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane (By similarity). Tissue Specificity: Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Similarity: Belongs to the IAN GTP-binding protein family. SWISS: Q8WWP7 Gene ID: 170575 Database links: Entrez Gene: 170575 Human Omim: 608084 Human SwissProt: Q8WWP7 Human Unigene: 647087 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验膜受体可将其分成非受体型和膜受体型。 1.非受体型 以src基因产物为代表,此外还有Yes、Fyn、Lck、Fgr、Lyn、Fps/Fes及Ab1等。徐后两者外,其余非受体型蛋白酪氨酸激酶src家族分子理约为60kDa的蛋白质,它们之间除了N末端80个氨基酸组成不同外,其作部分都非常相似。 2.受体型 根据它们的结构不同,受体型酪氨酸激酶可以分为9种类型,其中较常见的有4种类型(图8-5)。 (1)表皮生长因子受体(EGFR)家族:EGF-R家族成员包括EGF-R(分子量为170kDa
MAP 激酶相关途径 1.Ras蛋白与信号转导 原癌基因FaS产物p21ras的参与。p21ras(简称Ras蛋白)分子质量为2lkDa,属鸟苷酸结合蛋白,是小G蛋白家族中的一个重要成员。G蛋白分两类,除了此处的小G蛋白外,另一类为异源三聚体G蛋白(heterotrimerlc G protein)。异源三聚体G蛋白相关受体为七次跨膜型结构,是一个包括100多个成员的大家族(见第五章图5―10)。但只有小G蛋白家族直接参与抗原诱导的T细胞识别信号转导。 Ras蛋白和鸟苷
),即 7-跨膜蛋白,是当今临床与科研药物的单一治疗靶点,也是迄今发现最大的靶点家族。据推测人基因组中,该家族的功能成员超过300个,涉及多种不同细胞与组织间的广泛信号途径。研究证实,对GPCR功能的调节,有助于免疫学、神经病学、心脏病学与肿瘤学领域多种疾病的治疗。 通过应用新的基于细胞水平的受体功能检测技术,候选药物对新调节子的确认率显著提高,损耗率(定义为临床前检测/临床试验失败率)降低。但基础研究获得的GPCR 功能数据很难被应用于临床疾病中。造成这种情况的原因是,传统细胞学实验往往(1)使用
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