- ¥1380 - 2200
- LMAI Bio
- LM-8110R
- 进口/国产
- 2025年12月11日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8110R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
UMPS
- 抗体名：
尿苷磷酸合成酶抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey
- 免疫原：
KLH conjugated synthetic peptide derived from human UMPS:351-450/480
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | UMPS |
| 中文名称 | 尿苷磷酸合成酶抗体 |
| 别 名 | ODC; Uridine 5-monophosphate synthase; OMPdecase; OPRT; OPRTase; Orotate phosphoribosyl transferase and orotidine 5' decarboxylase; Orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase phosphoribosyltransferase; Orotidine 5' phosphate decarboxylase; Orotidine 5''-phosphate decarboxylase; RP11-71H17.9; UMP synthase; Umps; UMPS_HUMAN; Uridine 5' monophosphate synthase; Uridine monophosphate synthetase. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UMPS:351-450/480 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Subunit: Homodimer. DISEASE: Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. Similarity: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. In the C-terminal section; belongs to the OMP decarboxylase family. SWISS: P11172 Gene ID: 7372 Database links: Entrez Gene: 460644 Chimpanzee Entrez Gene: 101124432 Gorilla Entrez Gene: 100070386 Horse Entrez Gene: 7372 Human Entrez Gene: 22247 Mouse Entrez Gene: 100173867 Orangutan Entrez Gene: 715664 Rhesus monkey Omim: 613891 Human SwissProt: P11172 Human SwissProt: P13439 Mouse SwissProt: Q5R514 Orangutan Unigene: 2057 Human Unigene: 13145 Mouse Unigene: 466951 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Hela(Human)Cell Lysate at 40 ug 293T (Human) Cell Lysate at 40 ug Primary: Anti-UMPS(bs-8110R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 52kD Observed band size: 52kD |
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文献和实验PNAS | 空间分辨代谢组学方法揭示“下游代谢物与上游代谢酶关联”的癌症相关代谢变化
表达的代谢酶：吡咯-5-羧酸还原酶 2(PYCR2)、谷氨酰胺酶(GLS)、尿苷磷酸化酶 1(UPase1)、组氨酸脱羧酶(HDC)、脂肪酸合成酶(FASN)和鸟氨酸脱羧酶(ODC)，它们广泛参与食管癌相关的肿瘤代谢过程，其中 PYCR2 和 UPase1 被首次发现在食管癌中异常改变。研究结果表明脯氨酸生物合成，谷氨酸代谢，尿苷代谢，组氨酸代谢，脂肪酸合成，多胺生物合成等代谢通路在食管癌组织中发生了显著变化。这些癌症代谢相关信息有助于增加对癌症代谢重编程的理解。 基于 AFADESI-MSI
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