- ¥1380 - 2200
- LMAI Bio
- LM-7645R
- 进口/国产
- 2025年12月12日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-7645R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
HCA57
- 抗体名：
肝癌相关抗原57抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human TID1/HCA57:101-200/480
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | HCA57 |
| 中文名称 | 肝癌相关抗原57抗体 |
| 别 名 | DnaJ (Hsp40) homolog subfamily A member 3; DnaJ homolog subfamily A member 3 mitochondrial precursor; DnaJ protein Tid 1; DnaJ protein Tid1; HCA57; Hepatocellular carcinoma associated antigen 57; Highly similar to HYPOTHETICAL 105.9 KD PROTEIN F22B7.5 IN CHROMOSOME; hTid 1; hTid1; III [Caenorhabditis elegans]; TID1; Tumorous imaginal discs (Drosophila) homolog; Tumorous imaginal discs protein Tid56 homolog; DNJA3_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TID1/HCA57:101-200/480 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: TID1 is a human homolog of the Drosophila tumor suppressor lethal tumerous imaginal discs and encodes two mitochondrial matrix localized splice variants of human Tid1 designated hTid1S and hTid1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid1L increases apoptosis induced by DNA damaging agents as mitomycin C and TNF alpha. A J domain mutant of hTid1L can dominantly suppress apoptosis and in sharp contrast the J domain mutant of hTid1S increases apoptosis. Expression of hTid1S and hTid1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti and pro apoptotic effects through discrete substrates and activities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals. Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Subunit: Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity). Subcellular Location: Mitochondrion matrix. Cytoplasm, cytosol (By similarity). Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK (By similarity). Tissue Specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. Post-translational modifications: Tyrosine phosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 CR-type zinc finger. Contains 1 J domain. SWISS: Q96EY1 Gene ID: 9093 Database links: Entrez Gene: 9093 Human Entrez Gene: 83945 Mouse Entrez Gene: 360481 Rat Omim: 608382 Human SwissProt: Q96EY1 Human SwissProt: Q99M87 Mouse Unigene: 459779 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验高内涵分析（HCA）整合了自动化图像获取功能和强大的图像分析函数，且通过单一实验就能测定多个细胞表型。我们利用HCA制定了一个新的神经毒性检测法。 0:05 神经元和星形胶质细胞共培养物的神经毒性高内涵分析5 0:48 内容简介48 1:28 准备用于神经毒性筛选的细胞88 2:57 细胞的固定和免疫荧光染色177 6:07 HCS成像、分析及其结果367 14:15 结论855 神经元和星形胶质细胞共培养物的神经毒性高内涵分析本视频来源于网络，如有异议请联系
更加明显，RA 持续时间更长，但其起病较缓慢，没有病情的波动和复发情况，也没有关节外皮肤及眼部表现的改变。 图为集萃药康 Male DBA/1J 诱导模型 3. 胶原抗体诱导的关节炎（CAIA） CAIA 属于 CIA 模型的扩展，是抗体诱导型关节炎模型中最常见的模型之一。与 CIA 依赖的 MHC 单倍型易感品系相比，CAIA 可在大多数小鼠上诱导关节炎，如 DBA/1、BALB/c、C57BL/6、C57BL/10 等小鼠[8]。 造模机制：通过靶向 Ⅱ 型胶原蛋白的各种表位的抗体混合
非酒精脂肪性肝炎（NASH）是一种无过量饮酒，以肝脏细胞脂肪变性、气球样变、弥散性肝小叶炎症为主要临床病理特征的综合征。它是非酒精脂肪性肝病（NAFLD）发展为肝硬化和肝癌的一个重要阶段。据报道 NAFLD 在发达国家的发病率表现为成人 30%、儿童 13%，其中大约有 10% 的 NAFLD 患者发展成为 NASH，而 NASH 患者中的 10% 会发展成为肝硬化，甚至肝癌。 非酒精脂肪性肝炎已经成为研究的焦点，然而 NASH 的发病机制尚未明确，研究发现其与胰岛素抵抗、氧化应激、瘦素
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