- ¥1380 - 2200
- LMAI Bio
- LM-5423R
- 进口/国产
- 2025年12月15日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5423R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PPAP2A
- 抗体名：
磷酸脂磷酸水解酶1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human PPAP2A:31-130/284 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PPAP2A |
| 中文名称 | 磷酸脂磷酸水解酶1抗体 |
| 别 名 | Lipid phosphate phosphohydrolase 1; Lipid phosphate phosphohydrolase 1a; LLP1a; LPP1; LPP1_HUMAN; PAP 2a; PAP-2a; PAP2; PAP2-alpha; PAP2a; PAP2a2; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; Phosphatidic acid phosphatase type 2A; Phosphatidic acid phosphohydrolase type 2a; PPAP2A; Type 2 phosphatidic acid phosphatase alpha; Type 2 phosphatidic acid phosphohydrolase. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 脂蛋白 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PPAP2A:31-130/284 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: PPAP2A is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. Function: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. Subunit: Homodimer. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas. Post-translational modifications: N-glycosylated. Contains high-mannose oligosaccharides. Similarity: Belongs to the PA-phosphatase related phosphoesterase family. SWISS: O14494 Gene ID: 8611 Database links: Entrez Gene: 8611 Human Omim: 607124 Human SwissProt: O14494 Human Unigene: 696231 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 2018.3.9取消WB，宋帅华。 |
| 产品图片 |  Blank control: H9C2 (blue) Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:100 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 3μl in 100 μL1X PBS containing 0.5% BSA(green). |
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文献和实验，是不可逆反应。所以脂肪酸的氧化产物乙酰CoA是不会转化为丙酮酸的，这种情况下式不会异生为葡萄糖的。再者，脂肪的水解产物甘油可以转变为磷酸二羟丙酮，这个物质可以异生为葡萄糖。7. 以谷物填喂家鸭，结果鸭体肥美多脂，试述此种鸭在填喂期间体内有何代谢特点？ 乙酰CoA 羧化酶催化的反应是脂肪酸合成的限速步骤，很多因素可影响此酶的活性。从而使脂肪酸合成速度改变，脂肪酸合成过程红的其他酶也可以被调节，如脂肪酸合酶，柠檬酸裂解酶。 在高脂膳食进食后，或因饥饿导致脂肪动员加强时，细胞内软酯酰CoA增多
结构和各类生物大分子在细胞内分布匹有所了解。 以肝细胞为例,蛋白质、酶及核酸在肝细胞内分布情况为: 细胞核: 精蛋白、组蛋白、核酸合成酶系 RNA占总量10%左右 DNA几乎全部 粒线体: 电子传递、氯化磷酸化、三羧酸循环、脂肪酸氧化、氨基酸氧化、脲合成等酶 系RNA占总量5%左右 DNA微量 内质网（微粒体）: 蛋白质合成酶系、羟化酶系 RNA占总量50%左右 溶酶体：水解酶系（包括核酸酶、磷酸脂酶、组织蛋白酶及糖苷及糖苷酶等） 高尔基氏体: 糖苷转移酶、粘多糖及类固醇合成酶系
酸脱氢酶。丁醇法对提取碱性磷酸脂酶效果也是十分显著的。胰岛素既能溶于稀酸、稀碱又能溶于酸性乙醇或酸性丙酮中。以60―70%的酸性乙醇提取效果最好，一方面可抑制蛋白质水解酶对胰岛素的破坏，同时也达到大量除去杂蛋白的目的。 e 表面活性剂的利用： 对于某些与脂质结合的蛋白质和酶，也有采用表面活性剂如胆酸盐及十二烷基硫酸钠等处理。表面活性剂有阴离子型（如脂肪酸盐、烷基苯磺酸盐及胆酸盐等），阳离子型（如氧化苄烷基二甲基铵等）及非离子型（Triton X-100 、TirtonX-114、吐温60 及吐温
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