- ¥1380 - 2200
- LMAI Bio
- LM-7546R
- 进口/国产
- 2025年12月16日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-7546R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
CD239
- 抗体名：
B细胞粘附分子CD239抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow,
- 免疫原：
KLH conjugated synthetic peptide derived from human CD239:201-300/623 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | CD239 |
| 中文名称 | B细胞粘附分子CD239抗体 |
| 别 名 | Antigen identified by monoclonal antibody F8; AU antibody Auberger B antigen; B CAM cell surface glycoprotein; B cell adhesion molecule; B-CAM cell surface glycoprotein; Basal cell adhesion molecule; Basal cell adhesion molecule Lu and Au blood groups; Basal cell adhesion molecule Lutheran blood group; Bcam; BCAM_HUMAN; CD239; CD239 antigen; F8/G253 antigen; Glycoprotein 95kDa; LU; Lutheran; Lutheran antigen; Lutheran blood group (Auberger b antigen included); Lutheran blood group Auberger b antigen included; Lutheran blood group glycoprotein; MSK19. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 心血管 细胞生物 信号转导 细胞膜受体 细胞粘附分子 细胞表面分子 血管内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 64kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD239:201-300/623 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Function: Laminin alpha-5 receptor. May mediate intracellular signaling. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Post-translational modifications: Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. SWISS: P50895 Gene ID: 4059 Database links: Entrez Gene: 4059 Human Entrez Gene: 57278 Mouse Entrez Gene: 78958 Rat Omim: 612773 Human SwissProt: P50895 Human SwissProt: Q9R069 Mouse SwissProt: Q9ESS6 Rat Unigene: 625725 Human Unigene: 29236 Mouse Unigene: 7003 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Blank control(blue): A549 (fixed with 2% paraformaldehyde for 10 min at 37℃). Primary Antibody:Rabbit Anti-CD239/AF647 Conjugated antibody (bs-7546R-AF647,Green); Dilution: 1ug in 100 uL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF647 (orange) ,used under the same conditions;  Blank control(blue): A549 (fixed with 2% paraformaldehyde for 10 min at 37℃). Primary Antibody:Rabbit Anti-CD239 antibody (bs-7546R,Green); Dilution: 1ug in 100 uL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions; Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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文献和实验。 一、粘附分子构型改变影响细胞的粘附作用 除了通过增加或降低粘附分子表达水平来调节细胞粘附能力外，某些因素还可以通过改变粘附分子的构型影响其与配体结合的亲和力，从而调节细胞的粘附能力，这使得对细胞粘附作用的调节更为精细和复杂。 （一）LFA-1分子构型改变对其粘附作用的影响 淋巴细胞在受到外来抗原，PMA，抗CD2、CD3、CD44、CD43或抗MACⅡ类分子单克隆抗体
在体内，一种细胞可能同时表达多种粘附分子，一种粘附分子也可以表达于多种不同的组织细胞，而细胞间的相互粘附作用又可能由多对粘附分子受体/配体共同参与，单从某一对粘附分子的作用难于了解细胞粘附作用的全过程。本节着重从粘附分子参与的体内某些生理或病理过程来介绍粘附分子的功能，并简述其分子基础。 一、炎症过程中白细胞与血管内皮细胞的粘附 炎症
在免疫细胞中，执行固有免疫功能的细胞:吞噬细胞、NK细胞等。执行适应性免疫功能:T、B淋巴细胞，还有APC细胞参与。 一、淋巴细胞 淋巴细胞分为B细胞和T细胞，分别来源于骨髓和胸腺B淋巴细胞 表面的BCR(mIg)及分泌的抗体均为免疫球蛋白。由B细胞介导的免疫称为体液免疫T淋巴细胞 ，TCR为双链分子。细胞毒性T细胞、调节性T细胞(Tr)（辅助性T细胞和抑制性T细胞）1.T淋巴细胞（T细胞） 胸腺依赖性淋巴细胞（thymus- dependent lymphocyte
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