- ¥1380 - 2200
- LMAI Bio
- LM-6895R
- 进口/国产
- 2025年12月12日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6895R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Fibrinogen gamma chain
- 抗体名：
纤维蛋白原γ链抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human Fibrinogen gamma chain:151-250/453
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | Fibrinogen gamma chain |
| 中文名称 | 纤维蛋白原γ链抗体 |
| 别 名 | FGG; FIBG_HUMAN; Fibrinogen gamma chain; Fibrinogen gamma polypeptide; fibrinogen gamma-b chain. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 心血管 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fibrinogen gamma chain:151-250/453 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Involvement in disease: Defects in FGG are a cause of thrombophilia. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen. Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. Subcellular Location: Secreted. Post-translational modifications: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin. DISEASE: Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: P02679 Gene ID: 2266 Database links: Entrez Gene: 2266 Human Entrez Gene: 99571 Mouse Omim: 134850 Human SwissProt: P02679 Human SwissProt: Q8VCM7 Mouse Unigene: 16422 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |
Sample: BRL-3A Cell (Rat) Lysate at 40 ug
Primary: Anti-Fibrinogen gamma chain (bs-6895R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 60 kD 
Sample: Hcclm3 Cell (Human) Lysate at 40 ug
Primary: Anti-Fibrinogen gamma chain (bs-6895R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 60 kD |
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文献和实验佚名 血液凝固的实质是纤维蛋白凝胶的生成，它是血浆中纤维蛋白原(fibrinogen)在凝血酶作用下降解为纤维蛋白并聚合成不溶性的网状结构。 纤维蛋白原分子由两对α�链、β－链及γ－链组成，每3条肽链(α、β、γ)绞合成索状，形成两条索状肽链，在N末端有二硫键使态个分子得到稳定。α及β肽链的N－端分别有一段16个及14个氨基酸的小肽，称为纤维肽A及B
抗体的结构 抗体是能与抗原特异性结合的免疫球蛋白(immunoglobulin,Ig)。Ig 分五类，即 IgG、IgA、IgM、IgD 和 IgE。与免疫测定有关的 Ig 主要为 IgG 和 IgM。Ig 由两个轻链（L）和两个重链（H）的单体组成。Ig 的轻链是相同的，有 κ（kappa）和 λ（Lambda）两种型别。五类 Ig 的重链结构不同，这决定了它们的抗原性也不同。IgG 和 IgM 的重链分别称为 γ（gamma）链和 μ（mu ）链。 重链和轻链的 N 端的氨基酸排列顺序
和λ型分别为95％和5％。一个抗体分子中的L链只有一种类型。λ链按其细微差别还可分出亚型(subtype)，人有λ1、λ2、λ3和λ4种亚型，小鼠则有λ1、λ2和λ3种亚型。H链的结构同L链相似，在N端有100—110个氨基酸的V区，其余部分为C区。C区有5种氨基酸序列，分别称为μ、γ、α、δ和ε。c区的长度在&alpha
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