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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-5764R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
CIAPIN1
- 抗体名:
细胞因子诱导凋亡抑制因子1
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Pig, Cow,
- 免疫原:
KLH conjugated synthetic peptide derived from human CIAPIN1 (101-200aa):51-150/312
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | CIAPIN1 |
| 中文名称 | 细胞因子诱导凋亡抑制因子1 |
| 别 名 | Anamorsin; CIAPIN 1; Cytokine induced apoptosis inhibitor 1; DRE2; CPIN1_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CIAPIN1 (101-200aa):51-150/312 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: CIAPIN1 (Cytokine induced apoptosis inhibitor 1) expression is dependent on growth factor stimulation. Overexpression confers resistance to apoptosis caused by IL3 deprivation. It may be required during hematopoiesis to mediate antiapoptotic effects of various cytokines. It also confers multidrug resistance in gastric cancer cells by upregulating the expression of MDR1 and MRP1. Function: May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitously expressed. Highly expressed in heart, liver and pancreas. Similarity: Belongs to the anamorsin family. SWISS: Q6FI81 Gene ID: 57019 Database links: Entrez Gene: 57019 Human Entrez Gene: 109006 Mouse Omim: 608943 Human SwissProt: Q6FI81 Human SwissProt: Q8WTY4 Mouse Unigene: 4900 Human Unigene: 27582 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Sample: Heart (mouse) Cell Lysate at 40 ug Primary: Anti- CIAPIN1(bs-5764R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34kD Observed band size: 36 kD ![]() Sample: Hcclm3 (human)cell Lysate at 40 ug Primary: Anti- CIAPIN1(bs-5764R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34kD Observed band size: 36 kD |
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文献和实验肿瘤细胞分泌免疫抑制因子 肿瘤细胞可分泌多种免疫抑制因子和表达某些蛋白分子,抑制调节性细胞因子的分泌,下调免疫效应细胞的活性,保护肿瘤细胞免受特异性CTL的杀伤。例如肿瘤细胞分泌的TGF-β、IL10和血管表皮生长因子(VEGF),具有负调节机体对肿瘤的免疫应答和促进肿瘤生长的作用。TNF是效应细胞分泌的杀伤肿瘤细胞的重要细胞因子,某些肿瘤细胞表达可溶性TNF结合蛋白(sTNF-BP),通过与TNF结合,阻止其与肿瘤细胞的TNF受体结合,抑制对肿瘤细胞的杀伤作用。
细胞因子的激活和炎症反应(见第七章)。而且,参与诱导凋亡的caspase分成两大类:启动酶(initiator)和效应酶(effector),它们分别在死亡信号转导的上游和下游发挥作用。经FADD激活的caspase 8属于启动酶。其他的启动酶还有caspase 9(参与线粒体介导的凋亡)和caspasel0(和颗粒酶诱导的凋亡有关)。Caspase的活性 受CrmA、杆状病毒蛋白P35、人XIAP蛋白及特异抑制性多肽DEVD―CH()等调节。
的生长因子(PDGF)、成纤维细胞生长因子(FGF)、肝细胞生长因子(HGF)、胰岛素样生长因子-I(IGF-1)、IGF-II、白血病抑制因子(LIF)、神经生长因子(NGF)、抑瘤素M(OSM)、血小板衍生的内皮细胞生长因子(PDECGF)、转化生长因子-α(TGF-α)、血管内皮细胞生长因子(VEGF)等。 重组细胞因子是利用基因工程技术在一定的宿主细胞中表达并经过一系列分离纯化工艺制备而成的细胞因子产品,目前已经广泛用于细胞治疗等相关研究领域和医药领域,如肿瘤、感染和造血障碍等疾病的治疗
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