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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-5725R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
APRIL/TNFSF13
- 抗体名:
肿瘤坏死因子配体超家族成员13抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat,
- 免疫原:
KLH conjugated synthetic peptide derived from human TNFSF13/APRIL:21-120/250
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | APRIL/TNFSF13 |
| 中文名称 | 肿瘤坏死因子配体超家族成员13抗体 |
| 别 名 | A proliferation inducing ligand; A proliferation-inducing ligand; APRIL; CD 256; CD256; CD256 antigen; Ligand; Proliferation inducing ligand APRIL; TALL 2; TALL-2; TALL2; TNF and APOL related leukocyte expressed ligand 2; TNF related death ligand 1; TNF related death ligand; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNF13_HUMAN; TNFSF 13; TNFSF13; TNFSF13 protein; TRDL 1; TRDL-1; TRDL1; Tumor necrosis factor (ligand) superfamily member 13; Tumor necrosis factor ligand superfamily member 13; Tumor necrosis factor related death ligand; Tumor necrosis factor related death ligand 1; Tumor necrosis factor superfamily member 13; TWE PRIL; ZTNF2. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 细胞周期蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNFSF13/APRIL:21-120/250 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Function: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Subunit: Homotrimer (Potential). Subcellular Location: Secreted. Tissue Specificity: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. Post-translational modifications: The precursor is cleaved by furin. Similarity: Belongs to the tumor necrosis factor family. SWISS: O75888 Gene ID: 8741 Database links: Entrez Gene: 8741 Human Entrez Gene: 69583 Mouse Entrez Gene: 287437 Rat Omim: 604472 Human SwissProt: O75888 Human SwissProt: Q9D777 Mouse Unigene: 54673 Human Unigene: 8983 Mouse Unigene: 19955 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Blank control(blue): Jurkat cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-APRIL/TNFSF13 antibody(bs-5725R), Dilution: 5μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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文献和实验-Trp基序和另外三个保守的半胱氨酸残基;②Ⅲ型纤连蛋白(FN3)型结构域:含有Trp-Ser-x-Trp-Ser(WSXWS)的保守序列,是结合配体和信号转导的基础;③免疫球蛋白C2型样(Ig样)结构域:每一个结构域大约有100个氨基酸残基。Ck和FN3结构域与Ig样结构域的空间结构相似。 细胞因子受体超家族结构图 主要包括免疫球蛋白受体超家族(1gR―SF)、I型细胞因子受体家族、Ⅱ型细胞因子受体家族(干扰素受体家族)、Ⅲ型细胞因子受体家族(肿瘤坏死因子受体
的不同成员中,β链相同,α链不同。已知α链和β链有20种左右的组合形式。表6-3概括了目前常见的粘合素超家族粘附分子β1、β2和β3组的结构及其相应配体。 表6-3 粘合素超家族粘附分子β1、β2、β3组结构及其相应配体 分组 成员 α/β亚单位 分子量(kD) 亚单位 结构 分布 配体 VLA组 (β1组) VLA-1 VLA-2 VLA-3 VLA-4 VLA-5 VLA
亚单位均由胞膜外区、胞浆区、穿膜区三部分组成。胞浆区一般较短,可能和细胞骨架相联。空膜区富含疏水氨基酸。β亚单位的胞膜外区含有4个富含半胱氨酸的重复序列,靠近外侧N端的40~50kDa的氨基酸残基通过链内二硫键紧密折叠在一起;α亚单位的胞膜外部分有7个同源重复序列,靠近外侧N端的3个或4个重复序列中含有Asp-X-Asp-X-Asp-Gly-X-X-Asp或类似结构,与integrin分子结合二价阳离子(Mg 2+ )有关,并与β亚单位共同构成粘合素分子的配体结合部位,其中α
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