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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-2205R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
SLAMF9
- 抗体名:
CD2F-10抗体
- 宿主:
Rabbit
- 适应物种:
Rat
- 免疫原:
KLH conjugated synthetic peptide derived from rat SLAMF9:51-150/285 <Extracellular>
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | SLAMF9 |
| 中文名称 | CD2F-10抗体 |
| 别 名 | SLAM family member 9; CD2 family member 10; CD2F-10; CD84 homolog 1; CD84-H1; 2310026I04Rik; AI462096; CD84-H1; MGC88194; SF2001; slamf9; SLAMF9. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat SLAMF9:51-150/285 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a member of the signaling lymphocytic activation molecule family. May play a role in the immune response. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants. Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP1-macrophage. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP1-macrophage. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: N/A Gene ID: 289235 Database links: Entrez Gene: 89886 Human Entrez Gene: 98365 Mouse Entrez Gene: 289235 Rat Omim: 608589 Human SwissProt: Q96A28 Human SwissProt: Q9D780 Mouse Unigene: 661712 Human Unigene: 150050 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验免疫应答的特点是抗体诱导潜伏期长(数天至2周),抗体效价低,早期为IgM类抗体,随后为IgG类,亲和力低,抗体持续时间短。再次应答诱导潜伏期短(1~2d甚至数小时);抗体效价为初次的数倍至数十倍;主要是亲和力强的IgG类,尚有IgA和IgE;维持时间长久,这是因为Bm经同一抗原反复刺激发生体细胞高突变和亲和力成熟。由于Tm表面CD2、LFA、ICAM等黏附分子和CD25、MHC分子等激活分子表达增加,使细胞间黏附能力增强,信号传递和与细胞因子应答加速,使再次细胞免疫应答大大加强。 抗感
CD2/CD2R 分子 CD2 常用单克隆抗体或代号:9.6,Tll,Leu5;(LFA 2,SRBC-R) 主要表达细胞:T,Thy,NKsub T细胞 分子质量(kDa)和结构:gp50(IgSF) 功 能:CD58、CD48、CD59和CDl50的受体,参与T细胞活化,参与细胞黏附 CD2R 常用单克隆抗体或代号:T11.3,9。1 主要表达细胞:Ta,NK T细胞 分子质量(kDa)和结构:gp50(IgSF) 功 能:T
(1)CD2:分子量约49kD的糖蛋白,表达于全部人T细胞和NK细胞表面;由3种抗原性不同的分子(CD2-1,CD2-2,CD2-3)组成。CD2-1及CD2-2表达于静止细胞表面,CD2-3表达于活化的T细胞表面。应用抗CD2-2及抗CD2-3可直接活化静止的T细胞,这是成熟T细胞活化的旁路途径。CD2是粘附分子之一,顺抗原递呈过程中起辅助作用。CD2分子还可与绵羊红细胞(SRBC)结合,又称绵羊红细胞受体。在一定条件下,将外周血淋巴细胞与SRBC混合,则血T细胞能结合若干SRBC
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