CD2/CD2R分子
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CD2/CD2R 分子
CD2
常用单克隆抗体或代号：9．6，Tll，Leu5；(LFA 2，SRBC-R)
主要表达细胞：T，Thy，NKsub T细胞
分子质量(kDa)和结构：gp50(IgSF)
功 能：CD58、CD48、CD59和CDl50的受体，参与T细胞活化，参与细胞黏附
CD2R
常用单克隆抗体或代号：T11．3，9。1
主要表达细胞：Ta，NK T细胞
分子质量(kDa)和结构：gp50(IgSF)
功 能：T细胞活化
CD2
Aka E rosette receptor, LFA-2 (leukocyte function antigen)
Function: binds CD58 / LFA-3 on antigen-presenting cells, and induces costimulatory signals in T cells
Also regulates T and NK-mediated cytolysis, inhibits apoptosis of activated peripheral T cells, mediates T cell cytokine production, regulates T cell anergy
Positive staining (normal): thymocytes (95%), mature peripheral T cells (almost all), NK cells (80-90%), thymic B cells (50%)
Micro images: extranodal NK/T cell lymphoma, nasal type
CD2R
CD2 epies restricted to activated T cells
Positive staining: activated T cells, ? NK cells
