Nogo R轴索过度生长抑制因子受体/Nogo受体抗体

Nogo R轴索过度生长抑制因子受体/Nogo受体抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-20486R
  • 进口/国产
  • 2025年11月07日
  • WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-20486R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Nogo R

    • 抗体名

      轴索过度生长抑制因子受体/Nogo受体抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat,

    • 免疫原

      KLH conjugated synthetic peptide derived from human Nogo R:331-430/473

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      100ul  200ul

    Nogo R轴索过度生长抑制因子受体/Nogo受体抗体
    英文名称 Nogo R
    中文名称 轴索过度生长抑制因子受体/Nogo受体抗体
    别    名 NgR; Nogo-66 receptor; Nogor; NogoR; Nogo-R; Reticulon 4 receptor; Rtn4r; RTN4R_HUMAN.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  神经生物学  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 48kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Nogo R:331-430/473 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

    Function:
    Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).

    Subunit:
    Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L.

    Subcellular Location:
    Cell membrane; Lipid-anchor, GPI-anchor.

    Similarity:
    Belongs to the Nogo receptor family. 
    Contains 8 LRR (leucine-rich) repeats. 
    Contains 1 LRRCT domain. 
    Contains 1 LRRNT domain.

    SWISS:
    Q9BZR6

    Gene ID:
    65078

    Database links:

    Entrez Gene: 65078 Human

    Entrez Gene: 65079 Mouse

    Entrez Gene: 113912 Rat

    Omim: 605566 Human

    SwissProt: Q9BZR6 Human

    SwissProt: Q99PI8 Mouse

    SwissProt: Q99M75 Rat

    Unigene: 30868 Human

    Unigene: 40149 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 Nogo R轴索过度生长抑制因子受体/Nogo受体抗体
    Sample:Cerebrum (Mouse)Lysate at 40 ug
    Primary: Anti-Nogo R(bs-20486R)at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
    Predicted band size: 48kD
    Observed band size: 48kD

    Nogo R轴索过度生长抑制因子受体/Nogo受体抗体
    Sample:Heart(Mouse)Lysate at 40 ug
    Primary: Anti-Nogo R(bs-20486R)at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
    Predicted band size: 48kD
    Observed band size: 48kD

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