- ¥780 - 2200
- LMAI Bio
- LM-1808R
- 进口/国产
- 2025年07月16日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-1808R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Haptoglobin
- 抗体名：
结合珠蛋白/触珠蛋白抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat,
- 免疫原：
KLH conjugated synthetic peptide derived from human Haptoglobin beta chain:251-350/406
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | Haptoglobin |
| 中文名称 | 结合珠蛋白/触珠蛋白抗体 |
| 别 名 | haptoglobin; Bp; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; Hp2 alpha; HP2 ALPHA2; HPA1S; HPT; MGC111141; HPT_HUMAN. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 生长因子和激素 激酶和磷酸酶 结合蛋白 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27/43kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Haptoglobin beta chain:251-350/406 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. Subunit: Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 2 Sushi (CCP/SCR) domains. SWISS: P00738 Gene ID: 3240 Database links: Entrez Gene: 3240 Human Entrez Gene: 15439 Mouse Entrez Gene: 24464 Rat Omim: 140100 Human SwissProt: P00738 Human SwissProt: Q61646 Mouse SwissProt: P06866 Rat Unigene: 513711 Human Unigene: 702099 Human Unigene: 26730 Mouse Unigene: 10950 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. haptoglobin是一种酸性糖蛋白,属α2唾液酸糖蛋白,主要由肝脏合成，也可在脂肪细胞、皮肤、脾、肌肉、肺内等合成。 |
| 产品图片 |  Sample: Hela(Human) Cell Lysate at 40 ug Primary: Anti-Haptoglobin (bs-1808R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27/43 kD Observed band size: 45 kD  Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-Haptoglobin (bs-1808R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27/43 kD Observed band size: 27 kD |
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文献和实验人结合珠蛋白/触珠蛋白前体(pre-Hpt/HAP)酶联免疫分析（ELISA）
人结合珠蛋白/ 触珠蛋白前体(pre-Hpt/HAP) 酶联免疫分析（ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中 结合珠蛋白 / 触珠蛋白前体 (pre-Hpt/HAP) 的 含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中人 结合珠蛋白 / 触珠蛋白前体 (pre-Hpt/HAP) 水平。用纯化的人 结合珠蛋白 / 触珠蛋白前体 (pre-Hpt/HAP) 抗体
蛋白直接被释放入血浆，与血浆中的结合珠蛋白（haptoglobin）�一种α2糖蛋白一结合，由于其分子较大，故不被肾脏排泄而被肝细胞摄取，最后变成胆红素。溶血较多时血浆中结合珠蛋白的浓度显著降低或消失，不过血浆中结合珠蛋白浓度的高低也受到其他多种因素的影响。 当血浆内结合珠蛋白全部与血红蛋白结合后，从游离血红蛋白分解出的血红素能与血结素（hemopexin）－一种β糖蛋白－结合，然后也被肝细胞摄取。大量溶血时血浆血结素的浓度亦降低。
C3、C4测定。 2、心血管疾病监测:载脂蛋白A、B，脂蛋白(a)，C-反应蛋白等。 3、炎症状况监测:C-反应蛋白，a-酸性糖蛋白，触珠蛋白，铜蓝蛋白等。 4、风湿性疾病检测：ASO、RF、CRP 5、肾脏功能检测：尿微量白蛋白，a-微球蛋白，β-微球蛋白，转铁蛋白，免疫球蛋白G等。 6、营养状态监测：白蛋白，前白蛋白，转铁蛋白等。 7、凝血及出血性疾病的检测：抗凝血酶Ⅲ，转铁蛋白，触珠蛋白等。 8、血脑屏障监测：脑脊液白蛋白，免疫球蛋白G、A、M。
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