- ¥1380 - 2200
- LMAI Bio
- LM-1779R
- 进口/国产
- 2026年08月20日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow,
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- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-1779R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
GATA5
- 抗体名：
GATA结合蛋白5抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow,
- 免疫原：
KLH conjugated synthetic peptide derived from human GATA-5:161-260/397
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | GATA5 |
| 中文名称 | GATA结合蛋白5抗体 |
| 别 名 | GATA binding protein 5; GATA-binding factor 5; GATA 5; GATA5; GATA-5; GATA5_HUMAN; Transcription factor GATA-5. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GATA-5:161-260/397 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. Function: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Subcellular Location: Nucleus. DISEASE: Note=Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Similarity: Contains 2 GATA-type zinc fingers. SWISS: Q9BWX5 Gene ID: 140628 Database links: Entrez Gene: 140628 Human Entrez Gene: 14464 Mouse Entrez Gene: 499951 Rat SwissProt: Q9BWX5 Human SwissProt: P97489 Mouse SwissProt: Q5U2V0 Rat Unigene: 352250 Human Unigene: 388880 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (Rat small intestine); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GATA5) Polyclonal Antibody, Unconjugated (bs-1779R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.  Paraformaldehyde-fixed, paraffin embedded (rat lung tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GATA5) Polyclonal Antibody, Unconjugated (bs-1779R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. |
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文献和实验人转录因子GATA结合蛋白3(GATA-3)ELISA试剂盒 说明书
人转录因子GATA 结合蛋白 3 ( GATA-3 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 GATA-3 单抗包被于酶标板上，标准品和样品中的 GATA-3与单抗结合，加入生物素化的抗人 GATA-3 ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合，加入
，常出现早期胚胎致死，而条件性敲除又无法复现完整表型，因此，缺乏能高度模拟Gata6基因突变引起的相关疾病的模型，严重制约了相关肝脏疾病机制的研究。 关键发现 本研究利用斑马鱼基因编辑技术进行了Gata6基因敲除，并借助Gata5代偿恢复血流，全面复现了人类Gata6基因突变引起的相关病变，并揭示了肝胆疾病致病机制，主要发现如下： 构建斑马鱼基因敲除模型：利用基因编辑技术获得两个等位基因，构建可长期存活的GATA6纯合敲除斑马鱼，全面再现人类Gata6突变相关多器官缺陷。大部分突变体在血流受阻
的主要表型标志物。这些标志物涵盖细胞表面分子（如CD45、CD127等）及转录因子（如Tbet、GATA3等）。 表格对比了NK细胞、ILC1、ILC2、ILC3及LTi细胞在不同物种间的表达差异，通过“+”、“-”或强度等级区分。值得注意的是，尽管总体模式保守，但部分标志物（如CD161、Sca-1）在小鼠和人类间存在显著区别，且某些标记物的表达受器官特异性影响。这为精准鉴定和区分各类ILCs提供了重要依据。 人固有淋巴细胞表型下图表展示了利用流式细胞术鉴定固有淋巴细胞（ILCs）及其亚群的通用
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