- ¥780 - 2200
- LMAI Bio
- LM-0736R
- 进口/国产
- 2025年07月13日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-0736R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
CD56
- 抗体名：
神经细胞粘附分子1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human CD56/NCAM1:701-800/858
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | CD56 |
| 中文名称 | 神经细胞粘附分子1抗体 |
| 别 名 | CD56 antigen; Cell Adhesion Molecule Neural 1; MSK39; N CAM 120; N CAM 140; N CAM 180; NCAM 1; NCAM 120; NCAM 140; NCAM1; Neural cell adhesion molecule 1 120 kDa isoform; Neural cell adhesion molecule 1 140 kDa isoform; Neural cell adhesion molecule 1; NCAM1_HUMAN. |
 |
Specific References (2) | bs-0736R has been referenced in 2 publications. [IF=5.68] Shi, Liang, et al. "Targeting Androgen Receptor (AR)→ IL12A Signal Enhances Efficacy of Sorafenib Plus NK Cells-Immunotherapy to Better Suppress HCC Progression." Molecular Cancer Therapeutics (2016): molcanther-0706. IHC-P ; Human. PubMed:26939703 [IF=3.26] Liu, Xin-Qi, et al. "Regulation of neuroendocrine cells and neuron factors in the ovary by zinc oxide nanoparticles." Toxicology Letters (2016). IHC-P ; Chicken. PubMed:27215404 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 细胞生物 神经生物学 干细胞 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 92kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD56/NCAM1:701-800/858 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] Function: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Subcellular Location: Isoform 1, 2,: Cell membrane; Single-pass type I membrane protein. Isoform 3, 4: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 5, 6: Secreted. Similarity: Contains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P13591 Gene ID: 4684 Database links: Entrez Gene: 4684 Human Entrez Gene: 17967 Mouse Entrez Gene: 24586 Rat Omim: 116930 Human SwissProt: P13591 Human SwissProt: P13595 Mouse SwissProt: P13596 Rat Unigene: 503878 Human Unigene: 711235 Human Unigene: 733031 Human Unigene: 439182 Mouse Unigene: 4974 Mouse Unigene: 11283 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞粘附蛋白（Call Adhesion Protein） 神经元标志物 NCAM-1为神经细胞粘附分子，主要分布于神经组织，神经—肌肉接头，神经—内分泌腺和某些内分泌腺以及大多数神经外胚层来源的细胞、组织和肿瘤中。 NCAM 1主要用于视网膜母细胞瘤、髓母细胞瘤、星形细胞瘤、神经母细胞瘤等肿瘤方面的研究。CD56（神经细胞黏附分子，NCAM）表达于大部分神经外胚层来源的细胞系、组织和肿瘤如视网膜母细胞瘤、成神经管细胞瘤、星形细胞瘤以及成神经细胞瘤。它也表达于一些中胚层来源的肿瘤如横纹肌肉瘤。NK细胞以及NK细胞淋巴瘤为阳性。CD56被认为是NK细胞肿瘤的重要标志物。该抗体识别分子量为180，145和125kDa亚型。 |
| 产品图片 |  Protein: Hela(human)cell lysates at 40ug; Primary: rabbit Anti-CD56 (bs-0736R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size:92 kD Observed band size:125 kD  Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NCAM1 Polyclonal Antibody, Unconjugated(bs-0736R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining  Blank control:Jurkat cells(blue). Primary Antibody:Rabbit Anti- CD56 antibody(bs-0736R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. Protocol The cells were fixed with 2% paraformaldehyde (10 min) . Primary antibody (bs-0736R,1μg /1x10^6 cells) were incubated for 30 min on the ice, followed by 1 X PBS containing 0.5% BSA + 10% goat serum (15 min) to block non-specific protein-protein interactions. Then the Goat Anti-rabbit IgG/PE antibody was added into the blocking buffer mentioned above to react with the primary antibody at 1/200 dilution for 30 min on ice. Acquisition of 20,000 events was performed. |
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文献和实验CD56 分子 CD56 常用单克隆抗体或代号： Leu19,NKH1;(NCAM) 主要表达细胞： NK,Tsub [NK] 分子质量(kDa)和结构： gp180(GPI连接,含FN结构域, 功 能：神经细胞粘附分子(N- CAM) 粘附,诱导杀伤活性 CD56 Aka N-CAM (neural cell adhesion molecule), at #11q23 Regulates homophilic
稳定表达在NK和LAK细胞表面的LAK-1分子，120kDa，NK细胞在IL-2条件下培养30天LAK-1仍为阳性，而HNK-1（CD57）和CD16部分消失。LAK的杀伤活性可被抗LAK-1McAb所抑制。 表7-10 检测人NK细胞常用的标志 CD/代表性McAb 识别膜成分 主要反应细胞 NK细胞中的阳性率（%） CD16/HUNK2，Leu11 FcγRⅢ NK，粒细胞，巨噬细胞，T亚群 80～90 CD56/NKH1,Leu19 N-CAM（神经细胞粘附分子）的异构
Cell Reports：上海科大朱焕乎团队揭示肠道营养信号如何指挥动物全身的发育进程
生出的小分子糖脂激素——蛔苷（Ascaroside），通过作用于位于线虫头部的化学感觉神经元纤毛上的激素受体 DAF-38，以及下游的核激素受体 DAF-12，来抑制葡萄糖神经酰胺缺失动物的发育。也就是说，肠道组织可以根据自身的营养感知信号，通过分泌小分子激素作用于中枢神经系统来调控发育进程。 总而言之，朱焕乎组在线虫中找到了一条通过体内脂质代谢物、营养感知通路、细胞器亚细胞定位及激素分泌来感知外界营养并调控发育的肠-脑轴通路。同时，研究人员也发现这种受营养环境调控的过氧化物酶体胞内分布在哺乳
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