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        CD56分子

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        CD56 分子

        CD56

        常用单克隆抗体或代号: Leu19,NKH1;(NCAM)

        主要表达细胞: NK,Tsub [NK]

        分子质量(kDa)和结构: gp180(GPI连接,含FN结构域,

        功 能:神经细胞粘附分子(N- CAM) 粘附,诱导杀伤活性

        CD56
        Aka N-CAM (neural cell adhesion molecule), at #11q23
        Regulates homophilic (like-like) interactions between neurons and between neurons and muscle
        Also associates with fibroblast growth factor receptor and stimulates tyrosine kinase activity of receptor to induce neurite outgrowth
        When neural crest cells s making N-CAM and N-cadherin and start displaying integrin receptors, cells separate and migrate
        Contributes to cell-cell or cell-matrix adhesion during development
        Lymphocyte activated killer phenomenon mediated by IL-2 activated CD56+, CD3-, NK cells
        Prototypic marker of NK cells, also present on subset of CD4+ and CD8+ T cells
        Positive staining (normal): NK cells (80-90%), activated T cells; cerebellum and brain at neuromuscular junctions, also normal neuroendocrine tissues
        Positive staining (tumors): myeloma, myeloid leukemia, neuroendocrine tumors, Wilm’s tumor, adult neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, small cell lung carcinoma
        Negative staining: PNET/Ewing’s sarcoma
        Micro images: testicular NK/T cell lymphoma (figure 3C), extranodal NK/T cell lymphoma, nasal type

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