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- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 详见说明书
- 详见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
受体结合丝氨酸苏氨酸激酶3抗体
- 抗体英文名：
Anti-RIPK3
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海一研
- 库存：
41
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
低温冷藏
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from human RIPK3
- 规格：
0.1ml/100μg 0.2ml/200μg
受体结合丝氨酸苏氨酸激酶3抗体说明书储存温度：
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
受体结合丝氨酸苏氨酸激酶3抗体说明书按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
公司所有产品低价促销，更有惊喜等你拿，超值好产品，预定受体结合丝氨酸苏氨酸激酶3抗体说明书即送好礼。好货提前订，快递更给力。产品质量好，到货快，质量三包。
英文名称 Anti-RIPK3
中文名称 受体结合丝氨酸苏氨酸激酶3抗体说明书
别 名 Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; Receptor interacting serine/threonine protein kinase 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3; RIPK3; RIPK3_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig
产品类型 一抗
研究领域 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 细胞膜受体
蛋白分子量 predicted molecular weight: 57kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RIPK3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains an N terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
Function : Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).
Subunit : Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.
Subcellular Location : Cytoplasm (By similarity). Cell membrane (By similarity). Mitochondrion (Potential).
Tissue Specificity : Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
Post-translational modifications : RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot:
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
受体结合丝氨酸苏氨酸激酶3抗体说明书的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
CLRN3/TMEM12跨膜蛋白12抗体规格:0.2ml
AKAP2蛋白激酶A2抗体规格:0.2ml
UBR2泛素蛋白连接酶E3α2抗体规格:0.2ml
MAP3K5/ASK1/MEKK5细胞凋亡信号调节激酶1抗体规格:0.1ml
Proteasome20Sbeta7蛋白酶体PSMβ7抗体规格:0.2ml
phospho-NFKBp65(Thr435)磷酸化细胞核因子抗体规格:0.1ml
COX7A2细胞色素c氧化酶7A2抗体规格:0.1ml
DonkeyAnti-GoatIgG/FITCFITC标记的驴抗羊IgG规格:0.3ml
phospho-GSK-3Beta(Ser9)磷酸化葡萄糖合成激酶3β抗体规格:0.1ml
CCDC23卷曲螺旋结构域蛋白23抗体规格:0.2ml
LIS1无脑回的致病基因LIS1抗体规格:0.2mlAtriopeptin I (rat) Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser(Disulfide bridge:Cys3-Cys19)
Biotin-Insulin Receptor (1142-1153), amide Biotin-Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-Tyr-Tyr-Arg-Lys-NH2
Bradykinin [Des-Arg1] Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Carassin (Carrassius Auratus) Ser-Pro-Ala-Asn-Ala-Gln-Ile-Thr-Arg-Lys-Arg-His-Lys-Ile-Asn-Ser-Phe-Val-Gly-Leu-Met-NH2
受体结合丝氨酸苏氨酸激酶3抗体说明书CKS-17 Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu
Decorsin, Leech Ala-Pro-Arg-Leu-Pro-Gln-Cys-Gln-Gly-Asp-Asp-Gln-Glu-Lys-Cys-Leu-Cys-Asn-Lys-Asp-Glu-Cys-Pro-Pro-Gly-Gln-Cys-Arg-Phe-Pro-Arg-Gly-Asp-Ala-Asp-Pro-Tyr-Cys-Glu
Endokinin A//B Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
Fmoc-Lys(Boc)-Leu-Lys(Boc) Fmoc-Lys(Boc)-Leu-Lys(Boc)
GLP-1 (7-36) amide (chicken, common turkey) His-Ala-Glu-Gly-Thr-Tyr-Thr-Ser-Asp-Ile-Thr-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Asn-Gly-Arg-NH2
HBV env (183–191) Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile
HIV-gp120-41-C Val-Pro-Trp-Asn-Ser-Ser-Trp-Ser-Asn-Lys-Leu-Asp-Arg-Ile-Trp-Asn-Asn-Met-Thr-Trp
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
受体结合丝氨酸苏氨酸激酶3抗体说明书按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
公司所有产品低价促销，更有惊喜等你拿，超值好产品，预定受体结合丝氨酸苏氨酸激酶3抗体说明书即送好礼。好货提前订，快递更给力。产品质量好，到货快，质量三包。
英文名称 Anti-RIPK3
中文名称 受体结合丝氨酸苏氨酸激酶3抗体说明书
别 名 Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; Receptor interacting serine/threonine protein kinase 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3; RIPK3; RIPK3_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig
产品类型 一抗
研究领域 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 细胞膜受体
蛋白分子量 predicted molecular weight: 57kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RIPK3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains an N terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
Function : Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).
Subunit : Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.
Subcellular Location : Cytoplasm (By similarity). Cell membrane (By similarity). Mitochondrion (Potential).
Tissue Specificity : Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
Post-translational modifications : RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot:
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
受体结合丝氨酸苏氨酸激酶3抗体说明书的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
CLRN3/TMEM12跨膜蛋白12抗体规格:0.2ml
AKAP2蛋白激酶A2抗体规格:0.2ml
UBR2泛素蛋白连接酶E3α2抗体规格:0.2ml
MAP3K5/ASK1/MEKK5细胞凋亡信号调节激酶1抗体规格:0.1ml
Proteasome20Sbeta7蛋白酶体PSMβ7抗体规格:0.2ml
phospho-NFKBp65(Thr435)磷酸化细胞核因子抗体规格:0.1ml
COX7A2细胞色素c氧化酶7A2抗体规格:0.1ml
DonkeyAnti-GoatIgG/FITCFITC标记的驴抗羊IgG规格:0.3ml
phospho-GSK-3Beta(Ser9)磷酸化葡萄糖合成激酶3β抗体规格:0.1ml
CCDC23卷曲螺旋结构域蛋白23抗体规格:0.2ml
LIS1无脑回的致病基因LIS1抗体规格:0.2mlAtriopeptin I (rat) Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser(Disulfide bridge:Cys3-Cys19)
Biotin-Insulin Receptor (1142-1153), amide Biotin-Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-Tyr-Tyr-Arg-Lys-NH2
Bradykinin [Des-Arg1] Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Carassin (Carrassius Auratus) Ser-Pro-Ala-Asn-Ala-Gln-Ile-Thr-Arg-Lys-Arg-His-Lys-Ile-Asn-Ser-Phe-Val-Gly-Leu-Met-NH2
受体结合丝氨酸苏氨酸激酶3抗体说明书CKS-17 Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu
Decorsin, Leech Ala-Pro-Arg-Leu-Pro-Gln-Cys-Gln-Gly-Asp-Asp-Gln-Glu-Lys-Cys-Leu-Cys-Asn-Lys-Asp-Glu-Cys-Pro-Pro-Gly-Gln-Cys-Arg-Phe-Pro-Arg-Gly-Asp-Ala-Asp-Pro-Tyr-Cys-Glu
Endokinin A//B Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
Fmoc-Lys(Boc)-Leu-Lys(Boc) Fmoc-Lys(Boc)-Leu-Lys(Boc)
GLP-1 (7-36) amide (chicken, common turkey) His-Ala-Glu-Gly-Thr-Tyr-Thr-Ser-Asp-Ile-Thr-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Asn-Gly-Arg-NH2
HBV env (183–191) Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile
HIV-gp120-41-C Val-Pro-Trp-Asn-Ser-Ser-Trp-Ser-Asn-Lys-Leu-Asp-Arg-Ile-Trp-Asn-Asn-Met-Thr-Trp
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文献和实验相关实验
蛋白丝氨酸／苏氨酸激酶 功能是使蛋白质上的丝氨酸和苏氨酸残基发生磷酸化。除了参与协同刺激信号的启动之外，这类激酶一般在信号转导的中下游发挥作用。由于信号途径具有相互“串流”(cross-talking)的特点，蛋白丝／苏氨酸激酶往往为各种免疫细胞和不同受体介导的信号途径所共用。与免疫细胞活化有关的丝／苏氨酸激酶主要有： 蛋白激酶C(PKC)：参与淋巴细胞激活信号转导的磷脂酰肌醇途径，激活转录因子NF-kB；
是一类磷酸转移酶，作用是把 ATP 的磷酸基转移到它底物的 某个蛋白的特定的氨基酸残基上面去，从而就改变了这个下游蛋白的构象。酪氨酸激酶 (PTK) 和丝氨酸 / 苏氨酸激酶 (STK)3、转录因子（transcription factors）对基因转录有调节作用的蛋白，那么细胞对信号转导有诸多 反应，最终都是涉及到蛋白和 DNA 相互识别和相互作用，引起一些基因表达 的改变，所以也有人把信号通路当中的转录因子统称为第 3 信使：第一信使是配体，与受体结合；第二信使是配体和受体结合之后激活的胞内
参与免疫细胞激活信号转导的蛋白磷酸酶 蛋白磷酸酶的作用和蛋白激酶相反。根据脱磷酸化的氨基酸残基的不同，蛋白磷酸酶也分成蛋白酪氨酸磷酸酶(PTP，PTPase)和丝氨酸／苏氨酸磷酸酶。参与淋巴细胞激活的蛋白磷酸酶主要有： ①CD45：该分子胞内段的两个结构域发挥PTP的作用，因而CD45属于受体型蛋白酪氨酸磷酸酶，在对抗瓢kPTK的作用和启动淋巴细胞信号转导中发挥关键作用； ②钙调磷酸
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受体结合丝氨酸苏氨酸激酶3抗体说明书
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