Shaker (KV1) Channel Blocker E

Shaker (K_V1) Channel Blocker Explorer Kit

A Screening Package of Shaker (K_V1) Channel Blockers Economically Priced
Cat #: EK-107
30 Vials

K⁺ selective channels are some of the most widespread ion trafficking molecules in living organisms, with more than 70 genes encoding different K⁺ channels in humans. 38 of those genes encode members of the K_V channel super family¹. K_V channels are composed of two types of protein subunits: the α subunit, which forms the pore and auxiliary (β) subunits. α subunits tetramerize in order to form a functional K⁺ conducting channel. The K_V α subunit is a protein with six transmembrane (TM) domains and intracellular N- and C-termini. The most defined structural features are the extracellular loop between the fifth and sixth TM (which forms the K⁺ selectivity filter and the channel pore) and the fourth TM, which is positively charged and forms the voltage sensor of the protein².

The pharmacological profile of K_V channels is quite impressive. Due to the large number and types of functional K_V channels, it became very important to identify the different native K_V currents in different tissues, cell types and developmental stages. Therefore, molecules that can specifically bind K_V channel components have become powerful tools in characterizing both the channel structure and its physiological role. Peptidyl toxins, mainly from scorpion and snake venoms, play a major role in identifying the various K_V channels. Such toxins include dendrotoxins from the green and black mamba snakes and agitoxins from scorpions.

Alomone Labs is pleased to offer the Shaker (K_v1) Channel Blocker Explorer Kit (#EK-107). This Explorer Kit is ideal for screening purposes.

• Compounds
• References
• Related Products

Product Name	Cat #	Size
Aa1	RTA-400	1 x 5 µg
ADWX-1	STW-100	1 x 0.1 mg
Agitoxin-1	RTA-150	1 x 5 µg
Agitoxin-2	STA-420	1 x 50 µg
Agitoxin-3	RTA-390	1 x 5 µg
Carvedilol	C-180	1 x 50 mg
Charybdotoxin	STC-325	1 x 0.1 mg
κ-Conotoxin RIIIJ	STC-660	1 x 5 µg
κ-Conotoxin RIIIK	STC-650	1 x 5 µg
CP 339818 hydrochloride	C-115	1 x 5 mg
α-Dendrotoxin	D-350	1 x 50 µg
β-Dendrotoxin	D-360	1 x 35 µg
γ-Dendrotoxin	D-370	1 x 70 µg
δ-Dendrotoxin	D-380	1 x 70 µg
Dendrotoxin-I	D-390	1 x 0.14 mg
Dendrotoxin-K	D-400	1 x 10 µg
Hemitoxin	STH-500	1 x 10 µg
Hongotoxin-1	RTH-400	1 x 5 µg
HsTx1	STH-300	1 x 0.1 mg
Kaliotoxin-1	STK-370	1 x 50 µg
Margatoxin	STM-325	1 x 0.1 mg
MCD peptide	STM-250	1 x 0.5 mg
Miconazole nitrate	M-206	1 x 1 g
Noxiustoxin	STN-340	1 x 5 µg
OsK-1	RTO-150	1 x 5 µg
Pandinotoxin Kα	STP-500	1 x 50 µg
ShK (Stichodactyla Toxin)	STS-400	1 x 0.1 mg
Tityustoxin-Kα	STT-360	1 x 5 µg
Trimethylapigenin	T-145	1 x 5 mg
UK-78282 hydrochloride	U-100	1 x 5 mg

References 

1. Wain, H.M. et al. (2002) Nucl. Acids Res. 30, 169.
2. Yellen, G. (2002) Nature 419, 35.