CaV1.2 Channel Basic Research

Ca_V1.2 Channel Basic Research Pack

All You Need for Ca_V1.2 Channel Research
Cat #: ESB-0100
8 Vials

Alomone Labs is pleased to offer the Ca_V1.2 Channel Basic Research Pack (#ESB-100). The Research Pack contains all you need for Ca_V1.2 research: Antibodies recognizing different domains of the channel, membrane lysates expressing Ca_V1.2 channel- your ideal control for western blot analysis and specific L-type Ca_V channel activators and blockers, all in one economical package!

• Compounds
• Scientific Background
• Related Products

Product Name	Cat #	Size
Anti-Human CaV1.2	ACC-022	1 x 0.2 ml
(±)-Bay K8644	B-350	1 x 10 mg
Isradipine	I-100	1 x 10 mg
CaV1.2 Channel Overexpressed Membrane Fractions	LX-104	2 x 0.1 ml
Anti-CaV1.2-ATTO-488	ACC-003-AG	1 x 50 µl

Scientific Background All L-type calcium channels are encoded by one of the Ca_V1 channel genes. These channels play a major role as a Ca²⁺ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All Ca_V1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the Ca_V1.1 and Ca_V1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of Ca_V1.2 is ubiquitous and Ca_V1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the Ca_V1 isoforms have been described. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700).
References 

1. Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579.
2. IUPHAR
3. Hu, X.Q. et al. (1998) J. Biol. Chem. 273, 5337.
4. Kreuzberg, U. et al. (2000) Am J. Physiol. 278, H723.
5. Allard, B. et al. (2000) J. Biol. Chem. 275. 25556.