Anti-MDA-treated low-density l

Anti-MDA-treated low-density lipoprotein (human, LDL)

Bioporto是一家体外诊断公司，专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。
官方网站：www.bioporto.com

Cat. No.

HYB 262-01

Product name

Anti-MDA-treated low-density lipoprotein (human, LDL)

Description

Mouse monoclonal antibody

Specificity

HYB 262-01 reacts with malonyldialdehyde (MDA)-treated LDL but not with native LDL.

Immunogen

Low-density lipoprotein purified from human plasma and treated with MDA

Application

ELISA, WB

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG2b/k

Gene ID

4018

Clone number

4C7

Epitope

Not determined

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. MDA-treated LDL appear to be different from LDL oxidized by other means.

Application 1

ELISA
HYB 262-01 reacts with MDA-treated LDL in ELISA.

Application 2

WB
HYB 262-01 reacts with MDA-treated LDL in SDS-PAGE immunoblotting.