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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Purified human complement C3 protein
- 亚型:
Mouse IgG2b
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
- 保存条件:
Store at -20°C.
- 克隆性:
单克隆抗体
- 标记物:
见下方详细说明
- 适应物种:
H
- 宿主:
Mouse
- 应用范围:
E
- 浓度:
见详细说明信息
- 靶点:
C3 Complement
- 抗体英文名:
C3 Complement Antibody
- 抗体名:
C3 Complement抗体
- 规格:
0.1 mg
C3 Complement Antibody产品详细介绍:
| 产品名称: | C3 Complement Antibody |
| 说明书: | http://www.abbiotec.com/antibodies/c3-complement-antibody【参考图片】 |
| 货号: | 250121 |
| 规格: | 0.1 mg |
| 产品描述: | The complement component C3 plays a central role in the activation of the complement system. C3 activation by the C3 convertase is the central reaction in both classical and alternative complement pathways. Cleaved C3 produces C3a anaphylatoxin, a mediator of local inflammatory process, and C3b, which binds to cell surface carbohydrates and immune aggregates. Genetic variation in C3 is associated with susceptibility to age-related macular degeneration 9 (ARMD9). This antibody recognizes the human complement C3 in ELISA. |
| 克隆类型: | Mouse Monoclonal Antibody |
| 亚型: | Mouse IgG2b |
| 免疫原: | Purified human complement C3 protein |
| 适用物种: | H |
| 应用范围: | E |
| 应用说明: | E: 5 ug/ml |
| 别名: | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3; C3a anaphylatoxin; Complement C3b alpha chain; Complement C3c alpha chain fragment 1; Complement C3dg fragment; C3d fragment; C3g fragment; C3f fragment; C3c alpha chain fragment 2 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: | Lindblom R et al. 2014. J Immunol. 192(3): 1138-1153. PMID# 24353269. |
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文献和实验Purification and Characterization of Human and Mouse Complement C3
Complement component C3 is the most abundant complement protein in plasma, central to all three complement activation pathways and essential to complement amplification. Thus, it is one of the most extensively studied complement proteins
一系列的酶,才具有溶菌、溶细胞的免疫活性。已知补体的激活途径有二:一是早期发现的经典途径,又称C1 通路;二是近年发现的替代途径,又称C3 旁路。 在补体激活的经典途径中,要有抗原抗体复合物存在,以及补体系统的11种蛋白质参加。在激活过程中,这11种蛋白成分可分为三种功能单位:识别单位,由Clq 、Clr 、和Cls 组成;激活单位,由C4 、C2 、C3 组成;攻击单位,由C5 、C6 、C7 、C8 和C9 组成。同一功能单位的补体分子具有化学亲合性,激活后可相互结合
动员感染、炎症反应、免疫反应,出现各种生物学活性的体液成分(主要为血清)之总称。存在于正常血清中,目前已知有 9种成分,分别称为 C1, C2, C3,… C9。 C1和 C2遇热则弱,在 56℃处理 30分钟可灭活。补体含量因动物而不同,其成分亦不同。豚鼠血清中各种成分颇为均衡,含量亦多,因此为许多实验所采用。对 Ag-Ab按 C1, C4, C2, C3, C5, C6, C7, C8, C9的顺序进行反应;但也了解到有按不同顺序发生反应的。抗原为红细胞时,补体以上列
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