HeLa细胞、HeLa细胞、HeLa宫颈癌细胞

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HeLa细胞、HeLa细胞、HeLa宫颈癌细胞 HeLa细胞、HeLa细胞、HeLa宫颈癌细胞

细胞名称：Hela    人宫颈癌细胞
组织来源：宫颈腺癌
培养条件：MEM +10% FBS
形      态：贴壁；上皮细胞样
背      景：是第一个来自人组织和连续培养维持非整倍体上皮样细胞系。它由G.D.Gey等在1951年从31岁女性黑人的宫颈癌建立。经原始组织切片样品的重新观察，Jones等将其诊断为腺癌。已知该细胞系含有人乳头状瘤病毒18序列，需在2级生物安全防护台操作。该细胞角蛋白阳性，p53表达量较低，但表达正常水平的pRB（视网膜母细胞瘤抑制因子）。

 

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PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051
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Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028
McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)