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- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
+4°C 干燥
- 保质期：
12个月
- 英文名：
YM298198 hydrochloride
- 供应商：
上海汇谱仪器有限公司
- CAS号：
748758-45-4
- 规格：
10 mg
概述
- 产品名称
YM298198 hydrochloride - 描述
Potent， selective mGlu1 antagonist - 生物学描述
Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic in vivo.
Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration. - 纯度
> 99%
性能
- 化学名称
6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride - 分子量
378.92 - 化学结构
- 分子式
C18H22N4OS.HCl - CAS编号
748758-45-4 - PubChem识别号
45073464 - 存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in water to 100 mM - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- SMILES
Cl.CN(C1CCCCC1)C(=O)c3sc4nc2ccc(N)cc2n4c3C - 来源
Synthetic
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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