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- 文献和实验
- 技术资料
- 保存条件：
Store at -20°C
- 保质期：
12 months
- 英文名：
Genistein
- 供应商：
上海汇谱仪器有限公司
- CAS号：
446-72-0
- 规格：
10 mg
概述
- 产品名称
Genistein - 描述
Protein tyrosine kinase inhibitor. Anticancer agent. - 生物学描述
Phytoestrogen found in soy beans. Anticancer agent. Inihibits tyrosine protein kinase and DNA topoisomerase as well as possessing antioxidant and cell cycle inhibitor activity. Endocytosis inhibitor. - 纯度
> 99%
性能
- 化学名称
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one - 分子量
270.24 - 化学结构
- 分子式
C15H10O5 - CAS编号
446-72-0 - PubChem识别号
5280961 - 存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in DMSO to 100 mM - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- SMILES
Oc1ccc(cc1)C3=COc2cc(O)cc(O)c2C3=O - 来源
Synthetic
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文献和实验Tyrosine Kinase Inhibitors Against EGF Receptor-Positive Malignancies
. Herceptin (31 –35 ), for example, is an immunotherapeutic agent that binds to the extracellular domain of HER2 (also referred to as ErbB-2, a tyrosine kinase belonging to the same family as EGFR) at nanomolar levels. EGF-genistein (EGF-gen) is an EGFR
disease，2001，21(3)：397～416. [4] Liu XJ, Yang L, Mao YQ, et al.Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells.World J Gastroenterol，2002,8(4):739～745. [5] Liu XJ, Yang L
，或两者兼具] genetic transformation|遗传转化[例如一个品系的生物吸收另一品系生物的遗传物质，并获 得后一品系某些遗传性状] genetic typing|遗传分型[例如根据人白细胞抗原（HLA）基因的限制性 片段长度多态性对个体进行分型] Geneticin|[商]遗传霉素[一种氨基糖苷类抗生素，Life Technologies公司（GIBCO）的商标] genistein
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