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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
+4°C 干燥
- 保质期：
12个月
- 英文名：
(S)-(+)-Rolipram
- 供应商：
上海汇谱仪器有限公司
- CAS号：
85416-73-5
- 规格：
10 mg
概述
- 产品名称
(S)-(+)-Rolipram - 描述
PDE4 inhibitor; less active enantiomer - 生物学描述
PDE4 inhibitor (IC50 = 0.58 μM). Less active enantiomer. - 纯度
> 99%
性能
- 化学名称
(S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one - 分子量
275.35 - 化学结构
- 分子式
C16H21NO3 - CAS编号
85416-73-5 - PubChem识别号
158758 - 存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in DMSO to 100 mM - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- SMILES
COc2ccc(cc2OC1CCCC1)[C@@H]3CC(=O)NC3 - 来源
Synthetic
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文献和实验Enzymatic Synthesis of (S)-Phenylalanine and Related (S)-Amino Acids by Phenylalanine Dehydrogenase
substituents in the reductive amination reaction. Optically pure (S)-phe and other (S)-amino acids are quantitatively synthesized from their oxo-analogs using PheDH, with a regeneration of NADH by formate dehydrogenase from Candida boidinii No. 2201. Acetone
have led to the conclusion that CYP2C19 is a major P450 responsible for (S)-mephenytoin 4’-hydroxylation activity in human liver microsomes (1 , 2 ). This is supported by the finding that cDNA-expressed CYP2C19 has a 50-to lOO-fold greater turnover number
A reverse-phase, high-performance liquid chromatography method is described for the quantification of 4′-hydroxymephenytoin formed enzymatically from 14 C-labeled (S )-mephenytoin following incubation with cDNA-expressed CYP2C19 or human
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