手机验证
4°C
详见说明
(S)-(+)-Rolipram
充足
杭州昊鑫生物
85416-73-5
10mg
生物活性 | (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
(+)-Rolipram (0.015-1000 μM; 20 h) dose-dependently suppress LPS-induced TNF production of human mononuclear cells (MNC), with an IC50 of 550 nM[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
(+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 | 275.34 |
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Formula | C16H21NO3 |
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CAS 号 | |||||||||||||
中文名称 | (S)-(+)-咯利普兰;(+)-咯利普兰 |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL (363.19 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
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