CD4 单克隆抗体

免疫组织化学（IHC）已验证样本:Human stomach,Mouse brain
免疫荧光（IF）已验证样本:Mouse colonic

IHC 1:100-1:300, IF 1:50-200

Monoclonal

IgG

Synthetic Peptide

CD4

CD 4;CD4 (L3T4);CD4;CD4 antigen (p55);CD4 antigen;CD4 molecule;CD4 receptor;CD4+ Lymphocyte deficiency;included;CD4;CD4mut;L3T4;Leu3;Ly-4;Lymphocyte antigen CD4;MGC165891;OTTHUMP00000238897;p55;T cell antigen T4;T cell antigen T4/LEU3;T cell differentiation antigen L3T4;T cell OKT4 deficiency;included;T cell surface antigen T4/Leu 3;T cell surface antigen T4/Leu3;T cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;W3/25;W3/25 antigen抗体

P01730

Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Protein A purification

Cancer; Immunology; Stem Cells

Clone:9G1

Unconjugated

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.