Recombinant Mouse CTLA4 / CD152 Protein (ECD, Fc Tag)
库存:
99
供应商:
北京义翘神州科技股份有限公司
规格:
100 µg/1 mg
规格:
100 µg
产品价格:
¥1660.0
规格:
1 mg
产品价格:
¥10760.0
小鼠 CTLA-4蛋白|CTLA-4 protein|CTLA-4(Mouse, C-human IgG1-Fc)(产品说明)
蛋白名称:CTLA-4蛋白, CTLA-4 protein
蛋白构建:A DNA sequence encoding the extracellular domain of mouse CTLA4 (NP_033973.2) (Met 1-Phe 162) was fused with the Fc region of human IgG1 at the C-terminus.
表达宿主:HEK293 Cells
蛋白纯度:> 95 % as determined by SDS-PAGE
蛋白活性:Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.05-0.3μg/mL when stimulated with 1 μg/mL Recombinant Human B7-1/CD80.
蛋白内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
预测N端:Glu 36
蛋白分子量:The secreted recombinant mouse CTLA4/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 368 amino acids and has a predicted molecular mass of 41 kDa. As a result of glycosylation, the apparent molecular mass of rm CTLA4/Fc monomer is approximately 55 kDa in SDS-PAGE under reducing conditions.
蛋白NP号:NP_033973.2
蛋白氨基酸序列:Met1-Phe162
蛋白标签:C-human IgG1-Fc
蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
1, Passariello, M; et al. Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells. Cancers (Basel), Pubmed: 32781690
2, Jacobs, L; et al. DNA-based delivery of checkpoint inhibitors in muscle and tumor enables long-term responses with distinct exposure. Molecular Therapy