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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7364R |
| 英文名称 | TLR10/CD290 Rabbit pAb |
| 中文名称 | Toll样蛋白受体10抗体 |
| 英文别名 | CD 290; CD 290 antigen; CD290; CD290 antigen; MGC104967; MGC126398; MGC126399; OTTHUMP00000158729; OTTHUMP00000218162; TLR10; TLR10_HUMAN; Toll like receptor 10; Toll-like receptor 10; TLR10 toll-like receptor 10; UNQ315/PRO358. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Rat, Cow, Horse, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TLR10 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 92 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling |
| 组织特异性 | Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines. |
| 相似性 | Belongs to the Toll-like receptor family. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain. |
| 功能 | Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
)01252-X [pii] 10.1016/j.bpj.2010.10.004 (2010). 25. Baker, G.R., Sullam, P.M., & Levin, J. A simple, fluorescent method to internally label platelets suitable for physiological measurements. Am. J. Hematol. 56, 17-25, doi:10.1002/(SICI)1096-8652
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
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