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GPR84 Rabbit pAb(bs-13507R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-13507R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-13507R
    英文名称GPR84 Rabbit pAb
    中文名称G蛋白偶联受体84抗体
    英文别名G protein coupled receptor 84; G-protein coupled receptor 84; G protein coupled receptor EX33; GPCR 4; GPCR4; GPR 84; GPR84_HUMAN; GPR84(EX33); EX33; Inflammation related G protein coupled receptor EX33; Inflammation-related G-protein coupled receptor EX33; GPCR EX33; EX 33; GPCR GPR84;
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Cow, Horse, Sheep, Monkey)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GPCR EX33/GPR84
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量44 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR

    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes.
    相似性Belongs to the G-protein coupled receptor 1 family.
    功能Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates, and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. G protein receptor 84 (GPR84), a member of the GCPR 1 family, is an orphan GCPR expressed in bone marrow, brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta, intestine, lung and peripheral blood leukocytes. In activated T cells, GPR84 regulates early interleukin-4 (IL-4) gene expression

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample: bone (Rat) Lysate at 40 ug
    Primary: Anti- GPR84 (bs-13507R)at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 44kD
    Observed band size: 44 kD
    产品细节图片2
    Sample:
    SP2/0 (mouse)Cell Lysate at 40 ug
    Lung(mouse) Lysate at 40 ug
    HL-60 (human)Cell Lysate at 40 ug
    Muscle (mouse) Lysate at 40 ug
    Primary: Anti- GPR84 (bs-13507R)at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 44kD
    Observed band size: 44 kD
    产品细节图片3
    Sample:
    Lane 1: Blood cell (Mouse) Lysate at 40 ug
    Lane 2: Lung (Mouse) Lysate at 40 ug
    Lane 3: Bone (Rat) Lysate at 40 ug
    Lane 4: Lung (Rat) Lysate at 40 ug
    Lane 5: Cerebrum (Rat) Lysate at 40 ug
    Lane 6: Cerebellum (Rat) Lysate at 40 ug
    Lane 7: U937 (Human) Cell Lysate at 30 ug
    Lane 8: U87MG (Human) Cell Lysate at 30 ug
    Lane 9: THP-1 (Human) Cell Lysate at 30 ug
    Primary: Anti-GPR84 (bs-13507R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 44 kD
    Observed band size: 44 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.4 }}] {Zheng Yanan. et al. Targeting GPR84 to alleviate acute immune-mediated liver injury. MOL MED. 2025 Dec;31(1):1-15} {WB,IHC} {Mouse}

    [IF={{ 5.893 }}] {Yongxiang Li. et al. Food reward depends on TLR4 activation in dopaminergic neurons. Pharmacol Res. 2021 Jul;169:105659} {WB} {Mouse}

    [IF={{ 5.561 }}] {Weijie Zhao. et al. Mannan Oligosaccharides Promoted Skeletal Muscle Hypertrophy through the Gut Microbiome and Microbial Metabolites in Mice. FOODS. 2023 Jan;12(2):357} {WB} {Mouse}

    [IF={{ 15.9 }}] {Xuenan Sun. et al. GPR84-mediated signal transduction effects metabolic function by promoting brown adipocyte activity. J CLIN INVEST. 2023 Oct;:} {IF} {Mouse}

    [IF={{ 10.9 }}] {Jinyan Liu. et al. MDSCs-derived GPR84 induces CD8+ T-cell senescence via p53 activation to suppress the antitumor response. J IMMUNOTHER CANCER. 2023 Nov;11(11):e007802} {WB,FCM} {Mouse}

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    文献支持
    GPR84 Rabbit pAb(bs-13507R)-50ul/100ul/200ul
    ￥1180 - 2800