CAST | Calpastatin Rabbit pAb(bs-6701R)-50ul/100ul/200ul产品图
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CAST | Calpastatin Rabbit pAb(

bs-6701R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-6701R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-6701R
    英文名称Calpastatin Rabbit pAb
    中文名称钙蛋白酶抑制蛋白抗体
    英文别名BS 17; Calpain inhibitor; Calpastatin; CAST; Heart type calpastatin; ICAL_HUMAN; MGC9402; Sperm BS 17 component; Sperm BS-17 component.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Cow)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Calpastatin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量70 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol I Transcription

    Epigenetics and Nuclear Signaling > Transcription > RNA polymerase

    翻译后修饰The N-terminus is blocked.
    相似性Belongs to the protease inhibitor I27 (calpastatin) family.
    功能Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Calpains are nonlysosomal, calcium-activated intracellular cysteine proteases that mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins. Calpain-1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Cal-pain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Calpastatin) Polyclonal Antibody, Unconjugated (bs-6701R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片2
    Sample:
    _x000D_ Lane 1: Human MDA-MB-231 cell lysates
    _x000D_ Lane 2: Human HepG2 cell lysates
    _x000D_ Lane 3: Human K562 cell lysates
    _x000D_ Lane 4: Human MCF-7 cell lysates
    _x000D_ Primary: Anti-Calpastatin (bs-6701R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 70 kDa
    _x000D_ Observed band size: 120 kDa
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded Human Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Calpastatin Polyclonal Antibody, Unconjugated (bs-6701R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.

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    图标文献和实验
    该产品被引用文献

    [IF=2.7] Zhang Cui. et al. Mitochondria-associated endoplasmic reticulum membrane (MAM)-associated calpains system in preeclampsia. BMC PREGNANCY CHILDB. 2025 Dec;25(1):1-12 WB,IF Human

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    CAST | Calpastatin Rabbit pAb(bs-6701R)-50ul/100ul/200ul
    ￥1180 - 2800