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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11105R |
| 英文名称 | Ninjurin 1 Rabbit pAb |
| 中文名称 | 神经损伤诱导蛋白1抗体 |
| 英文别名 | Nerve injury induced protein 1; Nerve injury-induced protein 1; NIN1; NINJ1; NINJ1_HUMAN; NINJURIN; Ninjurin-1. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Ninjurin 1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 16 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > Membrane Proteins Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration Tags & Cell Markers > Cell Type Markers > Epi / Endo-thelial |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. |
| 相似性 | Belongs to the ninjurin family. |
| 功能 | Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Ninjurin family proteins are muli-pass membrane proteins induced by nerve injury in Schwann cells and dorsal root ganglion neurons. Nunjurin proteins act as homophilic cell adhesion molecules that promote axonal growth. Ninjurin proteins also play a role in the formation and function of other tissues. Ninjurin-1 is widely expressed in adult and embryonic tissues, particularly those with epithelial origin. Ninjurin-2 is also widely expressed, with highest levels in adult bone marrow and peripheral blood lymphocytes and embryo liver, thymus and heart. The genes that encode the Ninjurin proteins map to a region known to cause several genetic disorders, including hereditary sensory neuropathy type I and type II (HSN1 and HSN2). However, no link between mutations in the genes encoding Ninjurins and the diseases have been found. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 9.587 }}] {Shi Yunhong. et al. N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1. J NEUROINFLAMM. 2023 Dec;20(1):1-18} {WB} {Mouse}
[IF={{ 9.3 }}] {Chen Lushu. et al. Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. J NEUROINFLAMM. 2024 Dec;21(1):1-16} {IF} {Mouse}
[IF={{ 6.086 }}] {Minoshima A et al. Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2358-2370.} {IHC} {Mouse}
[IF={{ 5.6 }}] {Chehao Lee. et al. Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. INT J MOL SCI. 2023 Jan;24(14):11554} {IF} {Mouse}
[IF={{ 3.68 }}] {Matsuki, Motoki, et al. "Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes." Circulation Journal 0 (2015).} {IHC} {="Mouse"}
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