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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6070R |
| 英文名称 | phospho-LLGL1 + LLGL2 (Ser650+Ser654) Rabbit pAb |
| 中文名称 | 磷酸化相似肿瘤抑制基因HUGL抗体 |
| 英文别名 | LLGL1+LLGL2(phospho S650+S654); LLGL1+LLGL2(phospho Ser650+Ser654); p-LLGL1+p-LLGL2(S650+S654); p-LLGL1/LLGL2(Ser650+Ser654); p-LLGL1/LLGL2(S650+S654); p-LLGL1/LLGL2(Ser650/654); DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL; L2GL1_HUMAN; L2GL2_HUMAN. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Chicken, Dog, Pig, Cow, Horse, GuineaPig, k) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from mouse LLGL1 around the phosphorylation site of Ser650+Ser654 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 117 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Notch Pathway Stem Cells > Neural Stem Cells > Intracellular Stem Cells > Neural Stem Cells > Surface Molecules Stem Cells > Signaling Pathways > Notch > Cytoplasmic Stem Cells > Signaling Pathways > Notch > Surface Molecules |
| 亚基 | Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. |
| 组织特异性 | Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at least at Ser-663 by PRKCI. |
| 相似性 | Belongs to the WD repeat L(2)GL family. Contains 14 WD repeats. |
| 功能 | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验. A Comprehensive Review of HER2 in Cancer Biology and Therapeutics. Genes (Basel). 2024 Jul 11;15(7):903.[12] Sun X, et al. Ki-67: more than a proliferation marker. Chromosoma. 2018 Jun;127(2):175-186.[13 ]S?rlie T, et al. Gene expression patterns of breast
The OP9-DL1 System: Generation of T-Lymphocytes from Embryonic or Hematopoietic Stem Cells In Vitro
-like-1 in vitro. Immunity 17: 749756.[Medline] Schmitt, T.M., de Pooter, R.F., Gronski, M.A., Cho, S.K., Ohashi, P.S., and Zúñiga-Pflücker, J.C. 2004. Induction of T cell development and establishment of T cell competence from embryonic stem cells
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. Cairns, P., Evron, E., Okami, K., Halachmi, N., Esteller, M., Herman, J.G., Bose, S., Wang, S.I., Parsons, R., and Sidransky, D. 1998. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder
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