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- bs-15510R
- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-15510R |
| 英文名称 | TYRP1 Rabbit pAb |
| 中文名称 | 酪氨酸酶相关蛋白1抗体 |
| 英文别名 | TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; TRP-1; b-PROTEIN; tyrosinase related protein 1; TYRRP; 5, 6-dihydroxyindole-2-carboxylic acid oxidase; EC:1.14.18; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TYRP1_HUMAN; |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TYRP1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 58 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Melanosome membrane; Single-pass type I membrane protein (By similarity). Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity). |
| 组织特异性 | Pigment cells. |
| 相似性 | Belongs to the tyrosinase family. |
| 功能 | Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TRP1 is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Primary: Anti-TRP1(bs-15510R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 58 kD
Observed band size: 55 kD
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文献和实验[IF={{ 7.971 }}] {Dvir Netanely. et al. Classification of node-positive melanomas into prognostic subgroups using keratin, immune, and melanogenesis expression patterns. Oncogene. 2021 Feb;:1-14} {IHC} {Human}
[IF={{ 5.395 }}] {Shubin Chong. et al. Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment. ACS BIOMATER-SCI ENG. 2023;XXXX(XXX):XXX-XXX} {WB} {Mouse}
[IF={{ 2 }}] {Zi-yi Xia. et al. Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR signaling Pathways. BIOL PHARM BULL. 2024 Jan 10} {WB} {Mouse,Human}
[IF={{ 1.65 }}] {Han, Joon‐Seung, Jong Hwan Sung, and Seung Kwon Lee. "Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen‐activated Protein Kinase in B16F10 Cells." Journal of Food Science (2016).} {WB} {="Mouse"}
[IF={{ 1.35 }}] {Cui, Yucong, et al. "The expression of KRT2 and its effect on melanogenesis in alpaca skins." Acta histochemica (2016).} {WB} {="Others"}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
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Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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