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- bs-3689R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-3689R |
| 英文名称 | IL3RB Rabbit pAb |
| 中文名称 | 粒细胞-巨噬细胞集落刺激因子受体β抗体 |
| 英文别名 | IL3RB; IL-3RB; IL-3R beta; GM-CSFR beta; IL 3 receptor beta; IL-5RB; IL-5R beta; IL 5 receptor beta; GM-CSFrβ; GM-CSF receptor beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; CSF2RB; IL3RB; IL5RB; GM CSF/IL 3/IL 5 receptor common beta chain; GM CSF/IL 3/IL 5 receptor common beta-chain; IL3RB; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity(granulocyte macrophage); Colony stimulating factor 2 receptor beta low-affinity(granulocyte macrophage); CSF2RB; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor(CDw131 antigen); Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta(high affinity); Interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor beta(high affinity); stimulating factor 3 receptor, beta(high affinity). |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GM-CSFR Beta |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 97 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors |
| 亚基 | Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. |
| 翻译后修饰 | May be phosphorylated by LYN. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. |
| 功能 | High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验该产品被引用文献
[IF={{ 4.739 }}] {Zsiros V et al. Endocytosis of GM-CSF receptor β is essential for signal transduction regulating mesothelial-macrophage transition. Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1450-1462.} {ICC,WB} {Rat}
[IF={{ 4.4 }}] {Jay Pundavela. et al. Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation. CANCERS. 2025 Jan;17(5):905} {IHC,IF} {Mouse}
[IF={{ 2.452 }}] {Chou YH et al.Erythropoietin modulates macrophages but not post-ischemic acute kidney injury in mice.(2018)J Formos Med Assoc. Nov 7. pii: S0929-6646(18)30506-0.} {IHC} {Mouse}
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IL3RB Rabbit pAb(bs-3689R)-50ul/100ul/200ul
￥1180 - 2800
