Blank control(blue): U-87MG(fixed with 2% Paraformaldehyde (10 min)).
Primary Antibody:Rabbit AntiFCGRT antibody(bs-13151R), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
- ￥1180 - 2800
- Bioss
- bs-13151R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-13151R |
| 英文名称 | FCGRT Rabbit pAb |
| 中文名称 | IgG-Fc片断受体转运蛋白α抗体 |
| 英文别名 | IgG receptor FcRn large subunit p51; Fc fragment of IgG, receptor transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor; FCGRN_HUMAN. |
| 产品应用 | WB=1:500-2000, Flow-Cyt=3μg/Test Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FCGRT/FcRn |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 37 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Adaptive Immunity > MHC > Class I Immunology > Immunoglobulins > Heavy Chain > IgG Immunology > Immunoglobulins > Receptors |
| 亚基 | FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). |
| 亚细胞定位 | Cell membrane. |
| 相似性 | Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
| 功能 | Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {Flow-Cyt} | {3μg/Test} |
Sample: bladder (Mouse)Lysate at 40 ug
Primary: Anti-FCGRT(bs-13151R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kD
Observed band size: 38 kD
Primary: Anti-FCGRT(bs-13151R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kD
Observed band size: 38 kD
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文献和实验该产品被引用文献
[IF={{ 1.64 }}] {Zhang, Wang-Dong, et al. "Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages." BMC Veterinary Research 12.1 (2016): 237.} {IHC} {="Others"}
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FCGRT Rabbit pAb(bs-13151R)-50ul/100ul/200ul
￥1180 - 2800
