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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2543R |
| 英文名称 | CLEC2 Rabbit pAb |
| 中文名称 | C型凝集素结构域家族1成员B抗体 |
| 英文别名 | C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721; CLC1B_HUMAN. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CLEC2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 27 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Cell Type Markers > CD > Myeloid Cells Immunology > Cell Type Markers > CD > NK Cells |
| 亚基 | Homodimer. |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein (Probable). |
| 组织特异性 | Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. |
| 翻译后修饰 | Glycosylated._x000D_
Phosphorylated on tyrosine residue in response to rhodocytin binding. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
Blank control(Blue): Hepg2 Cells(fixed with 2% Paraformaldehyde (10 min)). _x000D_
Primary Antibody: Rabbit Anti-CLEC2/FITC Conjugated antibody (bs-2543R /FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; _x000D_
Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.
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文献和实验该产品被引用文献
[IF=8.754] Xi-Xi Ni. et al. Regulation of the macrophage-hepatic stellate cell interaction by targeting macrophage PPARγ to prevent NASH progression in mice. LIVER INT. 2022 Sep;: IF Mouse
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CLEC1B | CLEC2 Rabbit pAb(bs-2543R)-50ul/100ul/200ul
￥1180 - 2800
