Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Bdkrb2/B2R Polyclonal Antibody, Unconjugated(bs-2422R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
- ￥1180 - 2800
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- bs-2422R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2422R |
| 英文名称 | BDKRB2 Rabbit pAb |
| 中文名称 | 缓激肽B2受体抗体 |
| 英文别名 | B2; B2 bradykinin receptor; B2BKR; B2BRA; B2R; BDKR B2; BDKRB 2; Bdkrb2; BK 2; BK 2 receptor; BK R2; BK2; BK2 receptor; BK2R; BKR 2; BKR2; BR B2; Bradykinin receptor b2; Bradykinin receptor beta 2; BRB 2; BRB2; DKFZp686O088; Kinin B2 Bradykinin receptor beta 2; B2R. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Bdkrb2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 43 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Acute Phase Reactants Cardiovascular > Vasculature > Vasodilation |
| 亚基 | Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Ubiquitous. Widespread in normal smooth muscle tissue and neurons. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily. |
| 功能 | Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Bradykinin increases vascular permeability, dilates blood vessels, contracts non-vascular smooth muscle, and causes pain. This product detects a receptor for bradykinin. The receptor is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Bradykinin B2 receptor expression has been reported in blood, brain, eye, kidney, liver, lung,prostate, skin, small intestine, synovium, uterus, and vessel. ESTs have been isolated from colon, connective tissue, heart, heart/melanocyte/uterus, kidney, lung, placenta, and thyroid libraries. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验该产品被引用文献
[IF={{ 5.6 }}] {Xiaoming. Qiu. et al. Bradykinin protects nucleus pulposus cells from tert-butyl hydroperoxide-induced damage and delays intervertebral disc degeneration. INT IMMUNOPHARMACOL. 2024 Jun;134:112161} {WB,IHC} {Rat,Human}
[IF={{ 5.076 }}] {Zhang Mengyang. et al. Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates. Oxid Med Cell Longev. 2021;2021:8877540} {IF} {Rat}
[IF={{ 4.996 }}] {Brusco Indiara. et al. Kinin B1 and B2 receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors. SCI REP-UK. 2023 Mar;13(1):1-16} {WB} {Mouse}
[IF={{ 4.358 }}] {Deng T et al. Di-(2-ethylhexyl) phthalate induced an increase in blood pressure via activation of ACE and inhibition of the bradykinin-NO pathway. Environ Pollut. 2019 Apr;247:927-934.} {IHC} {Mouse}
[IF={{ 4.148 }}] {Qin L et al. Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis. Arthritis Res Ther. 2019 Jan 8;21(1):12.} {IHC,WB} {Mouse}
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BDKRB2 Rabbit pAb(bs-2422R)-50ul/100ul/200ul
￥1180 - 2800
