Blank control(blue): U937(fixed with 2% Paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-CD112 antibody(bs-2679R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
econdary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
- ￥1180 - 2800
- Bioss
- bs-2679R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2679R |
| 英文名称 | CD112 Rabbit pAb |
| 中文名称 | 细胞粘附分子CD112抗体 |
| 英文别名 | Nectin-2; Nectin2; Nectin 2; CD 112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovirus receptor like 2; Poliovirus receptor related 2(herpesvirus entry mediator B); Poliovirus receptor related 2; Poliovirus receptor related protein 2; Poliovirus receptor-related protein 2; Nectin cell adhesion molecule 2; HVEB; PRR 2; PRR2; PVRL 2; PVRL2; NECT2_HUMAN; PVRR 2; PVRR2. |
| 产品应用 | Flow-Cyt=1μg /test Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD112 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 56 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudoRabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Probable cell adhesion protein. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudoRabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /test} |
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文献和实验该产品被引用文献
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自身免疫 性疾病，其临床特点为皮肤和粘膜的自发性的、松弛性的水疱形成，病理特点是由棘层松解引起的表皮内水疱。临床上可分为寻常型（PV）、红斑型、落叶型（PE）、增殖型、疱疹样型五型。 1．免疫荧光检查 应用IIF检查，天疱疮病人中85%～90%血清中有抗表皮棘细胞间抗体（Pab）存在，活动期更高。血清中Pab滴度与病情严重程度相平行。免疫荧光图形是棘细胞间均一的线型。作IIF检查时，底物很重要。Michael等比较猴食道及豚鼠食道上皮作为PV和PF的底物
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CD112 Rabbit pAb(bs-2679R)-50ul/100ul/200ul
￥1180 - 2800
