- 询价
- Abcam
- 中国/美国/德国
- xy10005-RP03
- 2025年07月12日
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- 详细信息
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CD112 / Nectin2 / PVRL2抗体
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human CD112 / Nectin2 extracellular domain (rhCD112; Catalog#10005-H08H; Met 1 - Leu 360; NP_002847.1). Total IgG was purified by Protein A affinity chromatography.
CD112 / Nectin2 / PVRL2抗体 Background
CD112, also known as Nectin2, is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. This protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
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