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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8596R |
| 英文名称 | GPR120 Rabbit pAb |
| 中文名称 | G蛋白偶联受体120抗体 |
| 英文别名 | G protein coupled receptor 120; GPCR GPR120; G protein coupled receptor 129; G protein coupled receptor GT01; G protein coupled receptor PGR 4; G protein coupled receptor PGR4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPR 120; GPR 129; GPR120; GPR129; GT01; HGNC:19345; MGC119984; O3FA1_HUMAN; O3FAR1; Omega-3 fatty acid receptor 1; PGR 4; PGR4; GPCR120. |
| 产品应用 | WB=1:500-2000, ICC/IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor 120 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 42 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation. |
| 亚细胞定位 | Cell membrane. Colocalized with ARRB2 following DHA treatment. |
| 组织特异性 | Abundant expression in the intestinal tract. |
| 翻译后修饰 | Phosphorylated. FFA stimulation facilitates phosphorylation. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ICC/IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 5.396 }}] {Xiaohua Yang. et al. Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17, 18-epoxyeicosatetraenoic acid and 19, 20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through GPR120-AMPKα signaling pathway. Food Funct. 2021 Dec;:} {WB} {Mouse}
[IF={{ 4.872 }}] {Chunling Huang. et al. Exposure to ethephon compromises endometrial decidualization in mice during early pregnancy via GPR120. Ecotox Environ Safe. 2021 Sep;220:112361} {WB} {Mouse}
[IF={{ 2.47 }}] {Meng, Yingying, et al. "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." Biochemical and Biophysical Research Communications (2017).} {WB} {="Mouse"}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
) and the fermentative hyperthermophiles, Pyrococcus furiosus (T opt = 100 �C) and Thermotoga maritima (T opt = 80 �C). Multi-well plates were incubated at various temperatures for approximately 72–120 h and then tested for growth. Positive growth resulting from single
Preparation of Calpastatin Samples for Western Blotting
% (5 ). Full-length calpastatins (made up of domains L and 1–4) from most tissues of human, rabbit, pig, and others, migrate as 110–120 kDa proteins in SDS-PAGE. However calpastatin from bovine heart migrates as a protein of 140–170 kDa (1 ), probably
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