PTTG1 | Securin Rabbit pAb(bs-1881R)-50ul/100ul/200ul产品图
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PTTG1 | Securin Rabbit pAb(bs-

1881R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-1881R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-1881R
    英文名称Securin Rabbit pAb
    中文名称垂体肿瘤转化基因抗体
    英文别名AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 ASSOCIATED PROTEIN 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG 1; PTTG; PTTG1; PTTG1 protein; PTTG1_HUMAN; Pttg3; Securin; TUMOR TRANSFORMING 1; Tumor transforming protein 1; TUMOR-TRANSFORMING 1; Tumor-transforming protein 1; TUTR 1; TUTR1.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Pig, Horse)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PTTG1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量22-28 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell cycle > Cell division

    Cell Biology > Cell Cycle > Cell Division > Chromatid Cohesion

    Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Chromatid Cohesion

    Epigenetics and Nuclear Signaling > Chromosome Structure > Cohesins

    亚细胞定位Cytoplasm. Nucleus.
    翻译后修饰Phosphorylated at Ser-165 by CDK1 during mitosis.
    _x000D_ Phosphorylated in vitro by ds-DNA kinase.
    _x000D_ Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
    相似性Belongs to the securin family.
    功能Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The encoded protein is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Protein: testis(mouse) lysate at 30ug;
    _x000D_ Primary: rabbit Anti- Securin (bs-1881R) at 1:300;
    _x000D_ Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000;
    _x000D_ Predicted band size: 28 kD
    _x000D_ Observed band size: 28 kD_x000D_
    产品细节图片2
    Protein: human colon carcinoma lysates at 30ug;
    _x000D_ Primary: Rabbit Anti-Securin(bs-1881R) at 1:200;
    _x000D_ Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000;
    _x000D_ ECL excitated the fluorescence;
    _x000D_ Predicted band size : 23kD
    _x000D_ Observed band size : 23kD
    _x000D_
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Securin) Polyclonal Antibody, Unconjugated (bs-1881R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Securin) Polyclonal Antibody, Unconjugated (bs-1881R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片5
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Securin) Polyclonal Antibody, Unconjugated (bs-1881R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF=4.2] Jin Cheng. et al. UBE2C/PTTG1 Regulates PANoptosis, Ferroptosis, and Autophagy to Improve Renal Ischemia–Reperfusion Injury. FASEB J. 2025 Dec;40(1):e71398 WB,IHC,IF Rat

    [IF=1.636] Shimoi G et al.Destabilization of spindle assembly checkpoint causes aneuploidy during meiosis II in murine post-ovulatory aged oocytes.(2019)J Reprod Dev. WB Mouse

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    PTTG1 | Securin Rabbit pAb(bs-1881R)-50ul/100ul/200ul
    ￥1180 - 2800