Sample:
Lane 1: Mouse Kidney Lysates
Lane 2: Rat Kidney Lysates
Primary: Anti-ASBT/SLC10A2 (bs-4189R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kDa
Observed band size: 38kDa
- ￥1180 - 2800
- Bioss
- bs-4189R
- 2025年10月24日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4189R |
| 英文名称 | SLC10A2 Rabbit pAb |
| 中文名称 | 顶膜钠依赖性胆盐转运体蛋白抗体 |
| 英文别名 | ASBT; Apical sodium dependent bile acid transporter; Apical sodium-dependent bile acid transporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na+bile acid cotransporter; Na+dependent ileal bile acid transporter; NTCP2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10(sodium/bile acid cotransporter family); Solute carrier family 10 member 2. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ASBT |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 38 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚基 | Monomer and homodimer. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. |
| 功能 | Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验该产品被引用文献
[IF={{ 8 }}] {Seho Kweon. et al. Coordinated ASBT and EGFR Mechanisms for Optimized Liraglutide Nanoformulation Absorption in the GI Tract. INT J NANOMED. 2024; 19: 2973–2992} {IF} {Dog,Human}
[IF={{ 7.9 }}] {Li Xiao. et al. Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling. PHYTOMEDICINE. 2023 Nov;120:155055} {WB} {Mouse}
[IF={{ 2.97 }}] {Wu, Hao, et al. "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." Phytomedicine (2014).} {WB} {=""}
[IF={{ 11.3 }}] {Kweon Seho. et al. Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery. Biomaterials Research. 2023 Dec;27(1):1-18} {WB} {Canine}
[IF={{ 1.69 }}] {Ding et al. Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats. (2015) Mol.Med.Re. 11:4431-7} {WB} {rat}
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SLC10A2 Rabbit pAb(bs-4189R)-50ul/100ul/200ul
￥1180 - 2800
