ABCC8 | SUR1 Rabbit pAb(bs-3641R)-50ul/100ul/200ul产品图
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ABCC8 | SUR1 Rabbit pAb(bs-364

1R)-50ul/100ul/200ul
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  • ¥1180 - 2800
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  • bs-3641R
  • 2026年10月13日
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      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-3641R
    英文名称SUR1 Rabbit pAb
    中文名称磺酰脲类药物受体1抗体
    英文别名ABC36; Abcc8; ATP binding cassette sub family C(CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8(1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Cow, Horse, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SUR1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量175 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Interacts with KCNJ11.
    亚细胞定位Membrane; Multi-pass membrane protein.
    相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample:
    _x000D_ Lane 1: Cerebrum (Mouse) Lysate at 40 ug
    _x000D_ Lane 2: Pancreas (Mouse) Lysate at 40 ug
    _x000D_ Lane 3: Stomach (Mouse) Lysate at 40 ug
    _x000D_ Lane 4: Cerebrum (Rat) Lysate at 40 ug
    _x000D_ Lane 5: SH-SY5Y (Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-SUR1 (bs-22836R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 177 kD
    _x000D_ Observed band size: 180 kD
    产品细节图片2
    Sample:
    _x000D_ Hippocampus (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-SUR1 (bs-3641R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 175 kD
    _x000D_ Observed band size: 175 kD

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    ABCC8 | SUR1 Rabbit pAb(bs-3641R)-50ul/100ul/200ul
    ¥1180 - 2800